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  4. Plasma soluble TREM2 is associated with white matter lesions independent of amyloid and tau
 
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Plasma soluble TREM2 is associated with white matter lesions independent of amyloid and tau

Journal
Brain : a journal of neurology
Journal Volume
144
Journal Volume
144
Journal Issue
11
Journal Issue
11
Pages
3371
Start Page
3371
End Page
3380
ISSN
0006-8950
Date Issued
2021-11-01
Author(s)
Tsai, Hsin-Hsi
YA-FANG CHEN  
RUOH-FANG YEN  
Lo, Yen-Ling
KAI-CHIEN YANG  
JIANN-SHING JENG  
LI-KAI TSAI  
CHE-FENG CHANG  
DOI
10.1093/brain/awab332
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/611230
URL
https://scholars.lib.ntu.edu.tw/handle/123456789/594324
Abstract
Cerebral small vessel disease is one of the most common causes of cognitive decline and stroke. While several lines of evidence have established a relationship between inflammation and cerebrovascular pathology, the mechanistic link has not yet been elucidated. Recent studies suggest activation of immune mediators, including the soluble form of triggering receptor expressed on myeloid cells 2 (TREM2), may be critical regulators. In this study, we compared the plasma levels of soluble TREM2 and its correlations with neuroimaging markers and cerebral amyloid load in 10 patients with Alzheimer's disease and 66 survivors of spontaneous intracerebral haemorrhage with cerebral amyloid angiopathy or hypertensive small vessel disease, two of the most common types of sporadic small vessel disease. We performed brain MRI and 11C-Pittsburgh compound B PET for all participants to evaluate radiological small vessel disease markers and cerebral amyloid burden, and 18F-T807 PET in a subgroup of patients to evaluate cortical tau pathology. Plasma soluble TREM2 levels were comparable between patients with Alzheimer's disease and small vessel disease (P = 0.690). In patients with small vessel disease, plasma soluble TREM2 was significantly associated with white matter hyperintensity volume (P < 0.001), but not with cerebral amyloid load. Among patients with Alzheimer's disease and cerebral amyloid angiopathy, plasma soluble TREM2 was independently associated with a tau-positive scan (P = 0.001) and white matter hyperintensity volume (P = 0.013), but not amyloid load (P = 0.221). Our results indicate plasma soluble TREM2 is associated with white matter hyperintensity independent of amyloid and tau pathology. These findings highlight the potential utility of plasma soluble TREM2 as a strong predictive marker for small vessel disease-related white matter injury and hold clinical implications for targeting the innate immune response when treating this disease.
Subjects
TREM2; cerebral amyloid angiopathy; cerebral small vessel disease; neuroinflammation; white matter hyperintensity
Publisher
OXFORD UNIV PRESS
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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