https://scholars.lib.ntu.edu.tw/handle/123456789/611665
標題: | An efficient approach to perform MR-assisted PET data optimization in simultaneous PET/MR neuroimaging studies | 作者: | Chen K.T. Salcedo S. Gong K. Chonde D.B. Izquierdo-Garcia D. Drzezga A. Rosen B. Qi J. Dickerson B.C. Catana C. TZE-HSIANG CHEN |
關鍵字: | fluorodeoxyglucose f 18;accuracy;algorithm;Alzheimer disease;anatomy aided reconstruction;Article;attenuation correction;brain metabolism;clinical article;controlled study;female;frontotemporal dementia;human;image artifact;image quality;image reconstruction;information processing;kernel method;male;mild cognitive impairment;motion correction;neuroimaging;nuclear magnetic resonance imaging;positron emission tomography;priority journal;process optimization;signal noise ratio | 公開日期: | 2019 | 卷: | 60 | 期: | 2 | 起(迄)頁: | 272-278 | 來源出版物: | Journal of Nuclear Medicine | 摘要: | A main advantage of PET is that it provides quantitative measures of the radiotracer concentration, but its accuracy is confounded by factors including attenuation, subject motion, and limited spatial resolution. Using the information from one simultaneously acquired morphologic MR sequence with embedded navigators for MR motion correction (MC), we propose an efficient method, MR-assisted PET data optimization (MaPET), for attenuation correction (AC), PET MC, and anatomy-aided reconstruction. Methods: For AC, voxelwise linear attenuation coefficient maps were generated using an SPM8-based method on the MR volume. The embedded navigators were used to derive head motion estimates for event-based PET MC. The anatomy provided by the MR volume was incorporated into the PET image reconstruction using a kernel-based method. Region-based analyses were performed to assess the quality of images generated through various stages of PET data optimization. Results: The optimized PET images reconstructed with MaPET were superior in image quality to images reconstructed using only AC, with high signal-to-noise ratio and low coefficient of variation (5.08 and 0.229 in a composite cortical region compared with 3.12 and 0.570, P, 10? 4 for both comparisons). The optimized images were also shown using the Cohen’s d metric to achieve a greater effect size in distinguishing cortical regions with hypometabolism from regions of preserved metabolism. Conclusion: We have shown that the spatiotemporally correlated data acquired using a single MR sequence can be used for PET attenuation, motion, and partial-volume effects corrections and that the MaPET method may enable more accurate assessment of pathologic changes in dementia and other brain disorders. COPYRIGHT ? 2019 by the Society of Nuclear Medicine and Molecular Imaging. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060905248&doi=10.2967%2fjnumed.117.207142&partnerID=40&md5=5383bef4d72ce9a474a05b4b06f7325d https://scholars.lib.ntu.edu.tw/handle/123456789/611665 |
ISSN: | 01615505 | DOI: | 10.2967/jnumed.117.207142 |
顯示於: | 醫學工程學研究所 |
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