MR-assisted PET motion correction in simultaneous PET/MRI studies of dementia subjects
Journal
Journal of Magnetic Resonance Imaging
Journal Volume
48
Journal Issue
5
Pages
1288-1296
Date Issued
2018
Author(s)
Chen K.T.
Salcedo S.
Chonde D.B.
Izquierdo-Garcia D.
Levine M.A.
Price J.C.
Dickerson B.C.
Catana C.
Abstract
Background: Subject motion in positron emission tomography (PET) studies leads to image blurring and artifacts; simultaneously acquired magnetic resonance imaging (MRI) data provides a means for motion correction (MC) in integrated PET/MRI scanners. Purpose: To assess the effect of realistic head motion and MR-based MC on static [18F]-fluorodeoxyglucose (FDG) PET images in dementia patients. Study Type: Observational study. Population: Thirty dementia subjects were recruited. Field Strength/Sequence: 3T hybrid PET/MR scanner where EPI-based and T1-weighted sequences were acquired simultaneously with the PET data. Assessment: Head motion parameters estimated from high temporal resolution MR volumes were used for PET MC. The MR-based MC method was compared to PET frame-based MC methods in which motion parameters were estimated by coregistering 5-minute frames before and after accounting for the attenuation-emission mismatch. The relative changes in standardized uptake value ratios (SUVRs) between the PET volumes processed with the various MC methods, without MC, and the PET volumes with simulated motion were compared in relevant brain regions. Statistical Tests: The absolute value of the regional SUVR relative change was assessed with pairwise paired t-tests testing at the P = 0.05 level, comparing the values obtained through different MR-based MC processing methods as well as across different motion groups. The intraregion voxelwise variability of regional SUVRs obtained through different MR-based MC processing methods was also assessed with pairwise paired t-tests testing at the P = 0.05 level. Results: MC had a greater impact on PET data quantification in subjects with larger amplitude motion (higher than 18% in the medial orbitofrontal cortex) and greater changes were generally observed for the MR-based MC method compared to the frame-based methods. Furthermore, a mean relative change of ?4% was observed after MC even at the group level, suggesting the importance of routinely applying this correction. The intraregion voxelwise variability of regional SUVRs was also decreased using MR-based MC. All comparisons were significant at the P = 0.05 level. Data Conclusion: Incorporating temporally correlated MR data to account for intraframe motion has a positive impact on the FDG PET image quality and data quantification in dementia patients. Level of Evidence: 3. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018;47:1288–1296. ? 2018 International Society for Magnetic Resonance in Medicine
Subjects
fluorodeoxyglucose f 18
Alzheimer disease
Article
clinical article
dementia
female
frontotemporal dementia
head movement
human
image quality
male
medial orbitofrontal cortex
mild cognitive impairment
motion correction
nuclear magnetic resonance imaging
observational study
positron emission tomography
priority journal
standardized uptake value ratio
aged
algorithm
artifact
brain
chemistry
diagnostic imaging
image processing
multimodal imaging
normal distribution
very elderly
Aged
Aged, 80 and over
Algorithms
Artifacts
Brain
Dementia
Female
Fluorodeoxyglucose F18
Head Movements
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Multimodal Imaging
Normal Distribution
Positron-Emission Tomography
SDGs
Type
journal article