The response of hepatocyte cell volume to hyperthermia and its role in oedema
Journal
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages
4305-4308
Date Issued
2011
Author(s)
Abstract
A novel mathematical model for hepatocytes and surrounding volume is presented here; in addition to tracking ion transport and diffusion the new model allows for changing cell volume. Using temporally and spatially varying temperature as an input, this paper shows how differences between diffusion coefficients directly influence increases in cell volume. The multiscale nature of the model presents a possible link from established cellular equations to the observed clinical result of oedema present in thermal treatments of cancer. ? 2011 IEEE.
Subjects
Cell volume
Diffusion Coefficients
Hepatocytes
Ion transports
Multiscale nature
New model
Varying temperature
Mathematical models
Cells
article
cell size
edema
fever
human
pathology
theoretical model
Cell Size
Edema
Fever
Humans
Models, Theoretical
SDGs
Type
conference paper