https://scholars.lib.ntu.edu.tw/handle/123456789/612493
標題: | Phytochemical-rich vegetable and fruit juice alleviates oral mucositis during concurrent chemoradiotherapy in patients with locally advanced head and neck cancer | 作者: | Chang, Hui Ping Huang, Meng Chuan Lei, Yen Ping Chuang, Yu Ju CHUN-WEI WANG LEE-YAN SHEEN |
關鍵字: | Carotenoids | Chemoradiotherapy | Oral mucositis | Phytochemicals | Polyphenols | 公開日期: | 1-一月-2022 | 來源出版物: | Journal of Traditional and Complementary Medicine | 摘要: | Background: Concurrent chemoradiotherapy (CCRT)-induced oral mucositis (OM) causes oral pain, malnutrition, and impaired quality of life in patients with head and neck cancer (HNC). Phytochemicals play a potential role in eliminating cancer therapy toxicity. Objective: To evaluate the effect of phytochemical-rich vegetable and fruit juice (VFJ) consumption in preventing CCRT-induced OM among patients with locally advanced HNC. Methods: Forty-nine patients with HNC undergoing CCRT were enrolled. All patients received nutritional counseling before CCRT and weekly follow-up. The VFJ group (25 patients) received 600 mL/day VFJ, 5 days/week for two weeks preceding CCRT and during CCRT, and the control group (24 patients) did not. The contents of total polyphenols and carotenoids in the VFJ were determined. Changes in anthropometric, dietary, and laboratory profiles were compared. Assessment of OM was based on the World Health Organization (WHO) scoring system. Results: Total polyphenols content was 64.6 mg gallic acid equivalents per 100 mL of the VFJ, and the main carotenoids were β-carotene and lycopene. The mean daily consumption of the VFJ was 538 mL for VFJ group. Changes in body weight, albumin, and energy intake were not significantly different between the two groups. The incidence of ulcerative OM was significantly lower in VFJ (64.0%) than in control (95.8%) subjects at week 6 of CCRT. Multiple logistic regressions revealed that VFJ consumption correlated significantly with lower risks of ulcerative OM. Conclusion: Consumption of VFJ rich in phytochemicals including total polyphenols and carotenoids effectively alleviates the severity of CCRT-induced OM among patients with locally advanced HNC. Section: Preventive Medicine; Dietary Therapy/Nutrition Supplements Taxonomy: (classification by EVISE)Preventive medicine, dietary therapy, nutrition supplements. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/612493 | ISSN: | 22254110 | DOI: | 10.1016/j.jtcme.2022.03.004 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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