https://scholars.lib.ntu.edu.tw/handle/123456789/612975
標題: | Changing epidemiology of shigellosis in Taiwan, 2010-2019: an emerging threat to HIV-infected patients and men who have sex with men | 作者: | Tsai, Chin-Shiang KUAN-YIN LIN Liou, Bo-Huang Chiou, Chien-Shun Lin, Yi-Chun Lee, Yuan-Ti Yang, Chia-Jui Tang, Hung-Jen Liao, Ying-Shu Liu, Chun-Eng Lee, Chen-Hsiang Lu, Po-Liang Huang, Sung-Hsi CHIEN-CHING HUNG Ko, Wen-Chien on behalf of the Taiwan HIV Study Group |
關鍵字: | Bacillary dysentery; antimicrobial resistance; fluoroquinolones; oro-anal sex; sexually transmitted disease | 公開日期: | 十二月-2022 | 出版社: | TAYLOR & FRANCIS LTD | 卷: | 11 | 期: | 1 | 起(迄)頁: | 498 | 來源出版物: | Emerging microbes & infections | 摘要: | Shigellosis appears to increase in certain at-risk populations in developed countries. Based on the nationwide surveillance, the annual incidence of shigellosis in Taiwan (1999-2019) was 0.38-5.77 cases per 100,000 people. Indigenous shigellosis has mostly affected men who have sex with men (MSM) and people living with HIV (PLWH) since 2015. In this retrospective study, compared with those diagnosed before 2015, indigenous cases diagnosed during 2015-2019 mostly occurred in male adults (96.0% vs 47.1%, P < 0.001), with a longer hospital stay (median 5.0 vs 3.5 days, P = 0.029) and different coinfections. The predominant strains in 2015 and 2016 were ciprofloxacin-resistant Shigella sonnei and azithromycin non-susceptible Shigella flexneri (S. flexneri) 3a, which had been replaced by ciprofloxacin-resistant S. flexneri 2a since 2018. Notably, six indigenous cases were caused by cefotaxime-resistant S. flexneri. Inappropriate use of empiric antibiotic treatment was common. In conclusion, there is an ongoing spread of ciprofloxacin-resistant shigellosis among PLWH and MSM and cefotaxime-resistant S. flexneri is an emerging threat in Taiwan. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/612975 | ISSN: | 2222-1751 | DOI: | 10.1080/22221751.2022.2031309 |
顯示於: | 醫學系 |
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