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  2. 醫學院
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Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/613057
Title: The correlation of forkhead box protein M1 (FOXM1) with gestational diabetes mellitus in maternal peripheral blood and neonatal umbilical cord blood
Authors: Chen, Han Ying
Chen, Ding ting
Chiang, Yen Yun
SHIN-YU LIN 
CHIEN-NAN LEE 
Keywords: Diabetes | Forkhead box protein M1 | Gestational
Issue Date: 1-Jan-2022
Source: Taiwanese Journal of Obstetrics and Gynecology
Abstract: 
Objective: The transcription activator FOXM1 was found to be essential for beta cell expansion and glucose homeostasis during pregnancy in a mouse model. We assumed that the mechanism would be similar in humans. Thus, we aimed to determine the correlation, if any, between FOXM1 and gestational diabetes mellitus in pregnant women. Materials and methods: Participants were recruited and collected from a single tertiary medical center in Taiwan. Participants' maternal peripheral blood was retrieved upon their admission for labor. The postpartum cord blood was harvested within 5 min after delivery of the fetus to test the FOXM1 mRNA expression level, as well as glucose, insulin, and C-peptide protein concentrations. Result: We recruited 83 pregnant women, 63 without GDM and 20 with GDM. The non-GDM maternal samples had a FOXM1ΔCt of 9.2 ± 1.53, whereas it was 8.92 ± 1.48 in the GDM group (p = 0.504). In the cord blood group, the GDM and non-GDM FOXM1ΔCt were 7.7 ± 1.02 and 7.95 ± 1.56, respectively (p = 0.416). Conclusion: This is the first study to prove a relationship between FOXM1 and GDM in humans. Although the exact linear correlation is still unknown, our results may provide an impetus for further research.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/613057
ISSN: 10284559
DOI: 10.1016/j.tjog.2022.02.045
SDG/Keyword: [SDGs]SDG3
Appears in Collections:醫學系

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