https://scholars.lib.ntu.edu.tw/handle/123456789/613286
標題: | Triterpene Acids from Mesona procumbens Exert Anti-inflammatory Effects on LPS-Stimulated Murine Macrophages by Regulating the MAPK Signaling Pathway | 作者: | Huang, Hung-Tse Liaw, Chia-Ching Chiou, Chun-Tang Kuo, Yao-Haur KUNG-TA LEE |
關鍵字: | MAPK; Mesona procumbens; NF-κB; anti-inflammatory; mesonaic acid | 公開日期: | 9-六月-2021 | 出版社: | American Chemical Society | 卷: | 69 | 期: | 22 | 起(迄)頁: | 6271-6280 | 來源出版物: | Journal of agricultural and food chemistry | 摘要: | Five new triterpene acids, mesonaic acids A-C (1-3), 2α,3α,19α-trihydroxy-24-nor-4(23),12-oleanadien-28-oic acid (4), and 3α,19α,22α-trihydroxy-2-oxo-12-ursen-28-oic acid (5), and 10 known triterpene acid compounds (6-15) were isolated from a methanolic extract of Mesona procumbens. Triterpenes 1-3 possess unusual hexacyclic skeletons with a 13α,27-cyclopropane ring. Regarding their anti-inflammatory activity, compounds 1-3, 6, and 7 inhibited NO production with EC50 values lower than 15 μM, which were better than that of the positive control quercetin. Compounds 1-3, 6, and 7 markedly decreased levels of the inducible iNOS and COX-2 proteins in macrophages by inhibiting the activation of NF-κB through interference with the MAPK signaling pathway. Based on these data, compounds 1-3, 6, and 7 have great potential as NO inhibitors. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/613286 | ISSN: | 0021-8561 | DOI: | 10.1021/acs.jafc.1c01810 |
顯示於: | 生化科技學系 |
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