https://scholars.lib.ntu.edu.tw/handle/123456789/613293
標題: | Mesonosides A-H, primeverose derivatives from Mesona procumbens suppress adipogenesis by downregulating PPARγ and C/EBPα in 3T3-L1 cells | 作者: | Huang, Hung-Tse Liaw, Chia-Ching Chiou, Chun-Tang KUNG-TA LEE Kuo, Yao-Haur |
關鍵字: | Anti-adipogenic; Lipid accumulation; Mesona procumbens; Mesonoside; PPAR gamma; ADIPOCYTE DIFFERENTIATION; GLYCOSIDES; EXTRACTS; OBESITY; DAMAGE | 公開日期: | 15-九月-2021 | 出版社: | Taiwan Food and Drug Administration | 卷: | 29 | 期: | 3 | 起(迄)頁: | 448-467 | 來源出版物: | Journal of food and drug analysis | 摘要: | Obesity is becoming a worldwide epidemic, especially in industrialized countries. We hereby report a methanolic extract of Mesona procumbens (known as Hsian-tsao in Taiwan) significantly inhibits lipid accumulation in 3T3-L1 adipocytes, and eight new primeverose derivatives, mesonosides A-H (1-8), were isolated from the methanolic extract of M. procumbens. Structural elucidation of 1-8 was established by spectroscopic methods, especially 2D NMR techniques (1H-1H COSY, HSQC, HMBC, and NOESY) and HRESIMS. Anti-obesity evaluation revealed that isolates 1-5, 7, and 8 showed inhibitory effects on lipid accumulation and protein levels of adipogenic transcription factor, PPARγ and C/EBPα in 3T3-L1 cells. Our study suggests that M. procumbens extract including new primeverose isolates may be potentially used as a natural source to ameliorate fat accumulation and even obesity. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/613293 | ISSN: | 1021-9498 | DOI: | 10.38212/2224-6614.3365 |
顯示於: | 生化科技學系 |
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