Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women
Journal
Human Molecular Genetics
Journal Volume
25
Journal Issue
3
Pages
620-629
Date Issued
2016
Author(s)
Wang Z.
Seow W.-J.
Shiraishi K.
Hsiung C.A.
Matsuo K.
Liu J.
Chen K.
Yamji T.
Yang Y.
Chang I.-S.
Wu C.
Ho J.C.M.
Chan J.K.C.
Wang J.-C.
Lu D.
Zhao X.
Zhao Z.
Wu J.
Chen H.
Jin L.
Wei F.
Hong Y.-C.
Wu G.
An S.-J.
Zhang X.-C.
Su J.
Wu Y.-L.
Gao Y.-T.
Xiang Y.-B.
He X.
Li J.
Zheng W.
Burdett L.
Shu X.-O.
Cai Q.
Klein R.
Pao W.
Lawrence C.
Hosgood H.D.
III, Hsiao C.-F.
Chien L.-H.
Chen Y.-H.
Chen C.-H.
Wyatt K.
Wang W.-C.
Chen C.-Y.
Wang C.-L.
Chen H.-L.
Su Y.-C.
Tsai F.-Y.
Chen Y.-S.
Li Y.-J.
Yang T.-Y.
Chung C.C.
Lin C.-C.
Wu T.
Lin D.
Zhou B.
Yu J.
Shen H.
Kubo M.
Chanock S.J.
Rothman N.
Li S.A.
Lan Q.
Yeager M.
Hutchinson A.
Hu W.
Caporaso N.
Landi M.T.
Chatterjee N.
Song M.
Fraumeni J.F.
Jr.
Kohno T.
Yokota J.
Kunitoh H.
Ashikawa K.
Momozawa Y.
Daigo Y.
Mitsudomi T.
Yatabe Y.
Hida T.
Hu Z.
Dai J.
Ma H.
Jin G.
Song B.
Wang Z.
Cheng S.
Yin Z.
Li X.
Ren Y.
Guan P.
Chang J.
Tan W.
Chen C.-J.
Chang G.-C.
Tsai Y.-H.
Su W.-C.
Huang M.-S.
Chen Y.-M.
Zheng H.
Li H.
Cui P.
Guo H.
Xu P.
Liu L.
Iwasaki M.
Shimazu T.
Tsugane S.
Zhu J.
Jiang G.
Fei K.
Park J.Y.
Kim Y.H.
Sung J.S.
Park K.H.
Kim Y.T.
Jung Y.J.
Kang C.H.
Park I.K.
Kim H.N.
Jeon H.-S.
Choi J.E.
Choi Y.Y.
Kim J.H.
Oh I.-J.
Kim Y.-C.
Sung S.W.
Kim J.S.
Yoon H.-I.
Kweon S.-S.
Shin M.-H.
Seow A.
Chen Y.
Lim W.-Y.
Liu J.
Wong M.P.
Lee V.H.F.
Bassig B.A.
Tucker M.
Berndt S.I.
Chow W.-H.
Ji B.-T.
Wang J.
Xu J.
Sihoe A.D.L.
Abstract
Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10(-13)), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10(-10)) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10(-9)). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.
SDGs
Publisher
Oxford University Press
Type
journal article