https://scholars.lib.ntu.edu.tw/handle/123456789/614526
標題: | Inhaled Corticosteroids Increase Risk of Nontuberculous Mycobacterial Lung Disease: A Nested Case-Control Study and Meta-analysis | 作者: | CHIN-CHUNG SHU Wei, Yu-Feng Chen, Kuang-Hung Chuang, Shulin Wang, Ya-Hui Wang, Cheng-Yi HAO-CHIEN WANG |
關鍵字: | inhaled corticosteroid; meta-analysis; nested case-control; nontuberculous mycobacterial lung disease | 公開日期: | 2022 | 出版社: | OXFORD UNIV PRESS INC | 卷: | 225 | 期: | 4 | 起(迄)頁: | 627 | 來源出版物: | The Journal of infectious diseases | 摘要: | Studies on use of inhaled corticosteroids (ICS) and the risk of nontuberculous mycobacterial lung disease (NTM-LD) are limited and have some conflicting results. We recruited 1235 NTM-LD patients and found that ICS use within 1 year was associated with increased NTM-LD, and the risk increased with elevated ICS dose and cumulative duration. Discontinuation of ICS use for more than 120 days could reduce the risk of NTM-LD to an insignificant level. For NTM species, the development of NTM-LD by ICS was highest for Mycobacterium kansasii lung disease. The pooled results of the meta-analysis showed that ICS use might increase the risk of NTM-LD with dose response in medium and high dose of daily ICS. In addition, budesonide had a smaller impact on the risk of NTM-LD than other ICS medications. The present study and meta-analysis provide evidence for ICS adjustment, including dose, discontinuation effect, and medications to possibly reduce the risk of NTM-LD. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/614526 | ISSN: | 0022-1899 | DOI: | 10.1093/infdis/jiab428 |
顯示於: | 醫學系 |
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