https://scholars.lib.ntu.edu.tw/handle/123456789/615010
Title: | Breast carcinoma-amplified sequence 2 regulates adult neurogenesis via β-catenin | Authors: | Chen, Hsin-Hsiung Lu, Hao-Yu Chang, Chao-Hsin Lin, Shih-Hao Huang, Chu-Wei Wei, Po-Han Chen, Yi-Wen Lin, Yi-Rou HSIEN-SUNG HUANG PEI-YU WANG Tsao, Yeou-Ping SHOW-LI CHEN |
Keywords: | AAV-DJ8; Adult neurogenesis; BCAS2; DCX+ immature neurons; Sox2+; β-catenin | Issue Date: | 2022 | Publisher: | BMC | Journal Volume: | 13 | Journal Issue: | 1 | Source: | Stem Cell Research & Therapy | Abstract: | Breast carcinoma-amplified sequence 2 (BCAS2) regulates β-catenin gene splicing. The conditional knockout of BCAS2 expression in the forebrain (BCAS2 cKO) of mice confers impaired learning and memory along with decreased β-catenin expression. Because β-catenin reportedly regulates adult neurogenesis, we wondered whether BCAS2 could regulate adult neurogenesis via β-catenin. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/615010 | ISSN: | 1757-6512 | DOI: | 10.1186/s13287-022-02837-9 |
Appears in Collections: | 腦與心智科學研究所 |
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