https://scholars.lib.ntu.edu.tw/handle/123456789/615868
標題: | Corneal transparency and scleral opacity arises from the nanoarchitecture of the constituent collagen fibrils | 作者: | Tseng S.H. Yang C.-Y. Li J.-H. YUNG-MING JENG Ranasinghesagara J.C. Venugopalan V. |
公開日期: | 2022 | 出版社: | Optica Publishing Group (formerly OSA) | 卷: | 13 | 期: | 3 | 起(迄)頁: | 1485-1496 | 來源出版物: | Biomedical Optics Express | 摘要: | While human scleral and corneal tissues possess similar structural morphology of long parallel cylindrical collagen fibrils, their optical characteristics are markedly different. Using pseudospectral time-domain (PSTD) simulations of Maxwell's equations, we model light propagation through realistic representations of scleral and corneal nanoarchitecture and analyze the transmittance and spatial correlation in the near field. Our simulation results provide differing predictions for scleral opacity and corneal transparency across the vacuum ultraviolet to the mid-infrared spectral region in agreement with experimental data. The simulations reveal that the differences in optical transparency between these tissues arise through differences in light scattering emanating from the specific nanoscale arrangement and polydispersity of the constituent collagen fibrils. © 2022 Optica Publishing Group. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125866697&doi=10.1364%2fBOE.444832&partnerID=40&md5=b569b67702cb3eafc449428079f69daf https://scholars.lib.ntu.edu.tw/handle/123456789/615868 |
ISSN: | 21567085 | DOI: | 10.1364/BOE.444832 | SDG/關鍵字: | Collagen; Histology; Light scattering; Maxwell equations; Tissue; Transparency; Collagen fibrils; Corneal tissues; Modeling light propagation; Nano-architecture; Near fields; Optical characteristics; Pseudospectral time domain; Spatial correlations; Structural morphology; Time-domain simulations; Opacity; collagen; anisotropy; architecture; Article; collagen fibril; computer model; controlled study; cornea opacity; cornea thickness; dispersity; electromagnetism; eye tracking; geometry; human; image segmentation; impedance spectroscopy; light propagation; light scattering; light transmission; mathematical model; measurement accuracy; multiphoton microscopy; optic disk; particle size; polarization; pseudospectral time domain simulation; refraction index; sclera; simulation; transmission electron microscopy; transmissivity; transmittance; two-dimensional imaging; ultraviolet radiation; uniform distribution; vacuum; water absorption |
顯示於: | 病理學科所 |
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