https://scholars.lib.ntu.edu.tw/handle/123456789/616089
標題: | Improving effect of a probiotic mixture on memory and learning abilities in D-galactose–treated aging mice | 作者: | Ho, Shang Tse Hsieh, Yueh Tung SHENG-YAO WANG MING-JU CHEN |
關鍵字: | aging | antioxidant | probiotic mixture | reactive oxygen species (ROS) | 公開日期: | 1-三月-2019 | 出版社: | ELSEVIER SCIENCE INC | 卷: | 102 | 期: | 3 | 起(迄)頁: | 1901 | 來源出版物: | Journal of Dairy Science | 摘要: | The aim of this study was to evaluate the antiaging effect of a probiotic mixture using an in vivo mouse model in which aging was induced with D-galactose. Results of the Morris water maze test indicated that long-term administration of the probiotic mixture improved memory and learning abilities and ameliorated the apoptosis pattern in the hippocampus of aging mice treated with D-galactose. An antioxidation experiment indicated that administration of the probiotic mixture could restore activities of the antioxidant enzymes superoxide dismutase and catalase and inhibit the production of malondialdehyde. The antioxidant-related proteins nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were upregulated in liver after treatment of D-galactose–treated aging mice with probiotics. Finally, the probiotic treatment did affect the production of short-chain fatty acids in D-galactose–treated aging mice. Our results highlighted a possible antioxidative effect triggered by short-chain fatty acids that contributed to improving the memory and learning abilities following treatment with the probiotic mixture and suggested that probiotics could serve as a therapy to modulate physiological function. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/616089 | ISSN: | 00220302 | DOI: | 10.3168/jds.2018-15811 |
顯示於: | 動物科學技術學系 |
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