https://scholars.lib.ntu.edu.tw/handle/123456789/617819
標題: | Various impacts of driver mutations on the PD-L1 expression of NSCLC | 作者: | Chu, Cheng-Hsiang Huang, Yen-Hsiang Lee, Po-Hsin Hsu, Kuo-Hsuan Chen, Kun-Chieh KANG-YI SU SUNG-LIANG YU Tseng, Jeng-Sen Yang, Tsung-Ying Chang, Gee-Chen |
公開日期: | 2022 | 卷: | 17 | 期: | 8 | 來源出版物: | PloS one | 摘要: | We aimed to evaluate whether different driver mutations have varying impacts on the programmed cell death-ligand 1 (PD-L1) expression of non-small cell lung cancer (NSCLC), and whether the prognostic roles of PD-L1 amongst our patients were divergent. This was a single-institute study that included patients with NSCLC. Six driver mutations, PD-L1 status, and the outcomes of treatment were assessed. A total of 1,001 NSCLC patients were included for analysis. Overall, the PD-L1 positive (TPS ≥ 1%) and strong positive (TPS ≥ 50%) rates were 52.2% and 17.3%, respectively. As compared with wild type lung adenocarcinoma, EGFR-mutant and HER2-mutant patients had similarly low PD-L1 and strong PD-L1 positive rates. BRAF-mutant patients had numerically higher PD-L1 and strong PD-L1 positive rates. Patients with fusion mutation (ALK and ROS1) (aOR 2.32 [95% CI 1.10-4.88], P = 0.027 and 2.33 [95% CI 1.11-4.89], P = 0.026), KRAS mutation (aOR 2.58 [95% CI 1.16-5.75], P = 0.020 and 2.44 [95% CI 1.11-5.35], P = 0.026), and non-adenocarcinoma histology (aOR 2.73 [95% CI 1.72-4.34], P < 0.001 and 1.93 [95% CI 1.13-3.30], P = 0.016) all had significantly higher PD-L1 and strong PD-L1 positive rates. A trend towards longer survival was noted in ROS-1 rearranged and KRAS-mutant patients with strong PD-L1 expression who had received crizotinib and chemotherapy, respectively. In conclusion, individual driver mutations had various impacts on the PD-L1 expression of NSCLC patients. The prognostic role of PD-L1 may also be divergent amongst patients harboring different driver mutations. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/617819 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0273207 |
顯示於: | 醫學檢驗暨生物技術學系 |
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