Chronic kidney disease, atherosclerosis, and cognitive and physical function in the geriatric group of the National Health and Nutrition Survey 1999-2002
Journal
Atherosclerosis
Journal Volume
202
Journal Issue
1
Pages
312-319
Date Issued
2009
Author(s)
Abstract
Background: This study was designed to elucidate the relationship between chronic kidney disease (CKD), atherosclerotic complications, and the effects on functional performance in the elderly. Methods: A total of 2431 subjects aged 65 and above from the National Health and Nutrition Survey (NHANES) 1999-2002 were included to formulate a population-based observational study. A structural equation model (SEM) was constructed to validate the relationship between renal impairment, atherosclerotic complications, and cognitive and physical function. Results: The results showed that renal impairment was independently associated with physical and cognitive function after adjustment of potential confounding factors (B = -0.12, p = 0.02). Renal impairment was positively associated with atherosclerotic complications (B = 0.26, p < 0.001), which was in turn negatively associated with functional performance (B = -0.24, p < 0.001). Variance analysis showed that 57% of the differences in physical and cognitive function could be attributed to CKD, CKD-associated atherosclerosis, and other cardiovascular risk factors. Conclusions: CKD may have impacts on the cognitive and physical function either directly or indirectly via atherosclerotic complications. © 2008 Elsevier Ireland Ltd. All rights reserved.
SDGs
Type
journal article