https://scholars.lib.ntu.edu.tw/handle/123456789/619159
標題: | Role of Dectin-1 in peripheral nerve injury | 作者: | Hsu, Angela Yu-Huey SUNG-TSANG HSIEH |
關鍵字: | Dectin-1; Wallerian degeneration; macrophage; peripheral nerve injury; peripheral nerve regeneration | 公開日期: | 2022 | 出版社: | FRONTIERS MEDIA SA | 卷: | 16 | 來源出版物: | Frontiers in cellular neuroscience | 摘要: | Dectin-1, a C-type lectin receptor, plays a role in nerve injury in the central nervous system. However, whether it plays a role in the peripheral nervous system is not well understood. Our study showed the expression of Dectin-1 on the membrane of macrophages. We also used a sciatic nerve crushing injury model to demonstrate that there was a delay in nerve degeneration-related processes such as breakdown of injured myelinated nerve fibers and formation of myelin ovoid in groups injected with whole glucan particle soluble (WGPS), a Dectin-1 antagonist. There were also fewer intraneural blood vessels in the Dectin-1 antagonist treated group. Our study suggested inhibiting Dectin-1 delayed debris clearance, nerve degeneration, and angiogenesis after peripheral nerve injury. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/619159 | ISSN: | 1662-5102 | DOI: | 10.3389/fncel.2022.810647 |
顯示於: | 解剖學暨細胞生物學科所 |
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