https://scholars.lib.ntu.edu.tw/handle/123456789/619716
標題: | TP53 mutations in de novo acute myeloid leukemia patients: Longitudinal follow-ups show the mutation is stable during disease evolution | 作者: | HSIN-AN HOU WEN-CHIEN CHOU Kuo, Y.-Y. Liu, C.-Y. LIANG-IN LIN Tseng, M.-H. Chiang, Y.-C. Liu, M.-C. Liu, C.-W. JIH-LUH TANG MING YAO Li, C.-C. SHANG-YI HUANG BOR-SHENG KO SZU-CHUN HSU Chen, Chien-Yuan Lin, C.-T. SHANG-JU WU WOEI TSAY YAO-CHANG CHEN HWEI-FANG TIEN |
公開日期: | 31-七月-2015 | 出版社: | Nature Publishing Group | 卷: | 5 | 期: | 7 | 起(迄)頁: | e331 | 來源出版物: | Blood Cancer Journal | 摘要: | The TP53 mutation is frequently detected in acute myeloid leukemia (AML) patients with complzhiyohuang@126.com t the stability of this mutation during the clinical course remains unclear. In this study, TP53 mutations were identified in 7% of 500 patients with de novo AML and 58.8% of patients with CK. TP53 mutations were closely associated with older age, lower white blood cell (WBC) and platelet counts, FAB M6 subtype, unfavorable-risk cytogenetics and CK, but negatively associated with NPM1 mutation, FLT3/ ITD and DNMT3A mutation. Multivariate analysis demonstrated that TP53 mutation was an independent poor prognostic factor for overall survival and disease-free survival among the total cohort and the subgroup of patients with CK. A scoring system incorporating TP53 mutation and nine other prognostic factors, including age, WBC counts, cytogenetics and gene mutations, into survival analysis proved to be very useful to stratify AML patients. Sequential study of 420 samples showed that TP53 mutations were stable during AML evolution, whereas the mutation was acquired only in 1 of the 126 TP53 wild-type patients when therapyrelated AML originated from different clone emerged. In conclusion, TP53 mutations are associated with distinct clinic-biological features and poor prognosis in de novo AML patients and are rather stable during disease progression. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84989808968&doi=10.1038%2fbcj.2015.59&partnerID=40&md5=556ed6267bead71aa19dce2840b8a25f https://scholars.lib.ntu.edu.tw/handle/123456789/619716 |
ISSN: | 2044-5385 | DOI: | 10.1038/bcj.2015.59 |
顯示於: | 醫學系 |
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