Oral microbiome and serological analyses on association of Alzheimer's disease and periodontitis
Journal
Oral Diseases
Date Issued
2023
Author(s)
Kuan-Lun Fu
Nawarat Wara-Aswapati
Cheng-Ning Yang
Abstract
OBJECTIVE: To investigate the association between Alzheimer's disease (AD) and periodontitis in the aspects of periodontal status, serological markers, and oral microbiome. MATERIALS AND METHODS: ), Tau, phosphorylated Tau (pTau), triglyceride, pro-inflammatory cytokines, and anti-Porphyromonas gingivalis lipopolysaccharide (LPS) antibody were examined. The saliva samples were analyzed for oral microbiome composition. RESULTS: pTau, and anti-P. gingivalis LPS antibody were strongly related to the gene upregulation in human pathogen septicemia. CONCLUSIONS: Our study suggested the association of periodontal infection and oral microbiome with AD. Further large-scale studies with longitudinal follow-up are warranted.
SDGs
Publisher
John Wiley and Sons Inc
Type
journal article