https://scholars.lib.ntu.edu.tw/handle/123456789/620604
標題: | Lipids and Lipoproteins in Health and Disease: Focus on Targeting Atherosclerosis | 作者: | CHIH-KUO LEE CHE-WEI LIAO SHIH-WEI MENG WEI-KAI WU JIUN-YANG CHIANG MING-SHIANG WU |
關鍵字: | apolipoprotein; high-density lipoprotein; lipoprotein(a); low-density lipoprotein; triglyceride | 公開日期: | 9-八月-2021 | 出版社: | MDPI | 卷: | 9 | 期: | 8 | 起(迄)頁: | 985 | 來源出版物: | Biomedicines | 摘要: | Despite advances in pharmacotherapy, intervention devices and techniques, residual cardiovascular risks still cause a large burden on public health. Whilst most guidelines encourage achieving target levels of specific lipids and lipoproteins to reduce these risks, increasing evidence has shown that molecular modification of these lipoproteins also has a critical impact on their atherogenicity. Modification of low-density lipoprotein (LDL) by oxidation, glycation, peroxidation, apolipoprotein C-III adhesion, and the small dense subtype largely augment its atherogenicity. Post-translational modification by oxidation, carbamylation, glycation, and imbalance of molecular components can reduce the capacity of high-density lipoprotein (HDL) for reverse cholesterol transport. Elevated levels of triglycerides (TGs), apolipoprotein C-III and lipoprotein(a), and a decreased level of apolipoprotein A-I are closely associated with atherosclerotic cardiovascular disease. Pharmacotherapies aimed at reducing TGs, lipoprotein(a), and apolipoprotein C-III, and enhancing apolipoprotein A-1 are undergoing trials, and promising preliminary results have been reported. In this review, we aim to update the evidence on modifications of major lipid and lipoprotein components, including LDL, HDL, TG, apolipoprotein, and lipoprotein(a). We also discuss examples of translating findings from basic research to potential therapeutic targets for drug development. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/620604 | ISSN: | 2227-9059 | DOI: | 10.3390/biomedicines9080985 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。