https://scholars.lib.ntu.edu.tw/handle/123456789/620618
標題: | A Novel Insight at Atherogenesis: The Role of Microbiome | 作者: | Kirichenko, Tatiana V Markina, Yuliya V Sukhorukov, Vasily N Khotina, Victoria A WEI-KAI WU Orekhov, Alexander N |
關鍵字: | TMAO; atherosclerosis; inflammation; lipoproteins; microbiome; mitochondria | 公開日期: | 22-九月-2020 | 出版社: | FRONTIERS MEDIA SA | 卷: | 8 | 起(迄)頁: | 586189 | 來源出版物: | Frontiers in cell and developmental biology | 摘要: | There is an important task of current medicine to identify mechanisms and new markers of subclinical atherosclerosis in order to develop early targets for the diagnosis and treatment of this disease, since it causes such widespread diseases as myocardial infarction, stroke, sudden death, and other common reasons of disability and mortality in developed countries. In recent years, studies of the human microbiome in different fields of medicine have become increasingly popular; there is evidence from numerous studies of the significant contribution of microbiome in different steps of atherogenesis. This review attempted to determine the current status of the databases PubMed and Scopus (until May, 2020) to highlight current ideas on the potential role of microbiome and its metabolites in atherosclerosis development, its mechanisms of action in lipids metabolism, endothelial dysfunction, inflammatory pathways, and mitochondrial dysfunction. Results of clinical studies elucidating the relationship of microbiome with subclinical atherosclerosis and cardiovascular disease considered in this article demonstrate strong association of microbiome composition and its metabolites with atherosclerosis and cardiovascular disease. Data on microbiome impact in atherogenesis open a wide perspective to develop new diagnostic and therapeutic approaches, but further comprehensive studies are necessary. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/620618 | ISSN: | 2296-634X | DOI: | 10.3389/fcell.2020.586189 |
顯示於: | 醫學系 |
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