Digital infarcts showing microangiopathy in adult dermatomyositis suggest severe pulmonary involvement and poor prognosis [3]
Journal
British Journal of Dermatology
Journal Volume
150
Journal Issue
6
Pages
1214-1216
Date Issued
2004
Author(s)
Abstract
cases were males and developed skin changes within 8 months after the chemotherapy. Raynaud's phenomenon and digital pitting scars were seen in two and one cases, respectively. The ANA was positive in three of the patients, although no case had scleroderma-specific autoantibodies. In seven patients, skin sclerosis was limited to the extremities, while only one showed skin sclerosis of the trunk as well as the extremities. The atypical distribution of skin involvement without sclerodactyly was specific for our case. Two cases showed morphoea-like plaques. None of the patients had a visceral involvement. Eight of nine cases had minimal persistent scleroderma after withdrawal of the drugs and additional treatments, including oral corticosteroids. Thus, the small incidence of Raynaud's phenomenon, digital pitting scars and ANA, and the absence of visceral involvement are characteristics of bleomycin-or peplomycin-induced scleroderma.
SDGs
Type
letter