https://scholars.lib.ntu.edu.tw/handle/123456789/621243
標題: | Druggable Targets and Compounds with Both Antinociceptive and Antipruritic Effects | 作者: | Weng, Hao-Jui Pham, Quoc Thao Trang Chang, Chia-Wei TSEN-FANG TSAI |
關鍵字: | neuropathy; pain; pruritus | 公開日期: | 19-七月-2022 | 出版社: | MDPI | 卷: | 15 | 期: | 7 | 來源出版物: | Pharmaceuticals (Basel, Switzerland) | 摘要: | Pain and itch are both important manifestations of various disorders, such as herpes zoster, atopic dermatitis, and psoriasis. Growing evidence suggests that both sensations have shared mediators, overlapping neural circuitry, and similarities in sensitization processes. In fact, pain and itch coexist in some disorders. Determining pharmaceutical agents and targets for treating pain and itch concurrently is of scientific and clinical relevance. Here we review the neurobiology of pain and itch and discuss the pharmaceutical targets as well as novel compounds effective for the concurrent treatment of these sensations. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/621243 | ISSN: | 1424-8247 | DOI: | 10.3390/ph15070892 |
顯示於: | 醫學系 |
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