https://scholars.lib.ntu.edu.tw/handle/123456789/621466
標題: | Intima-media thickness of lower-limb arteries associated with fasting and post-challenge plasma glucose levels. | 作者: | Ho, Hung-Chi MING-FONG CHEN HWANG, JUEY-JEN Lee, Yuan-Teh TA-CHEN SU |
公開日期: | 2009 | 卷: | 16 | 期: | 6 | 起(迄)頁: | 748-755 | 來源出版物: | Journal of atherosclerosis and thrombosis | 摘要: | AIM: Atherosclerosis is a systemic disease with focal cardiovascular events. Although the accelerated development of peripheral arterial disease in diabetic patients is well known, the pathogenic mechanism of site-specific susceptibility to glycemia is uncertain. OBJECTIVE: To investigate the association of fasting and post-challenge glucose levels with intima-media thickness (IMT) at different arterial sites. METHODS: Forty consecutive middle-aged volunteers aged 37 to 53 years were recruited to define the association of IMT with cardiovascular risk factors at 12 carotid and 6 lower-limb arterial sites. A linear mixed model was used to regress the primary outcome measures, which were repeated measures of IMT at multiple arterial sites (18 sites per participant), on fixed-effect predictors of various conventional cardiovascular risk factors, while accounting for the interdependence of repeated measures taken from the same participant with unstructured covariance. RESULTS: Carotid IMTs were associated independently with waist circumference and systolic blood pressure, whereas lower-limb IMTs were associated with waist circumference, low-density lipoprotein cholesterol (LDL-C), glycated hemoglobin A1C (HbA1C), and fasting and 2-hour post-challenge plasma glucose levels; these associations were stronger in overall arteries. Independent associations of ALT and smoking with IMT appeared only in overall arteries. CONCLUSION: In a middle-aged, nonclinical sample, lower-limb but not carotid IMTs are associated independently with HbA1C, and fasting and 2-hour post-challenge plasma glucose levels. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77950365600&doi=10.5551%2fjat.836&partnerID=40&md5=5ccd556aa4e8367bde8c8f83117d12c8 https://scholars.lib.ntu.edu.tw/handle/123456789/621466 |
ISSN: | 1880-3873 | DOI: | 10.5551/jat.836 |
顯示於: | 醫學系 |
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