https://scholars.lib.ntu.edu.tw/handle/123456789/621840
標題: | Heart-Ankle Pulse Wave Velocity Is Superior to Brachial-Ankle Pulse Wave Velocity in Detecting Aldosterone-Induced Arterial Stiffness | 作者: | ZHENG-WEI CHEN CHIEN-TING PAN CHENG-HSUAN TSAI Chang, Yi-Yao CHIN-CHEN CHANG BO-CHING LEE Chiu, Yu-Wei Huang, Wei-Chieh Lin, Yu-Li VIN-CENT WU CHI-SHENG HUNG CHE-WEI LIAO YEN-HUNG LIN On Behalf Of Taipai Study Group, null |
關鍵字: | arterial stiffness; brachial-ankle pulse wave velocity; heart-ankle pulse wave velocity; primary aldosteronism | 公開日期: | 22-九月-2021 | 出版社: | MDPI | 卷: | 9 | 期: | 10 | 起(迄)頁: | 1285 | 來源出版物: | Biomedicines | 摘要: | Primary aldosteronism (PA) is associated with higher arterial stiffness compared to essential hypertension (EH). However, few studies have compared different pulse wave velocity (PWV) parameters to detect aldosterone-induced arterial stiffness. In this study, we aimed to compare the sensitivity in detecting aldosterone-induced arterial stiffness between brachial-ankle PWV (baPWV) and heart-ankle PWV (haPWV). We prospectively enrolled 1006 PA patients and 983 EH patients. Detailed medical history, basic biochemistry data and two PWV measurements (baPWV and haPWV) were collected in both groups. We performed analysis on the original cohort and two propensity score matching (PSM) models (model 1 adjusted for age and sex; model 2 adjusted for age, sex, systolic and diastolic blood pressure). The DeLong test was used to compare areas under receiver operating characteristic curves (AUCs) between baPWV and haPWV to predict PA. In all models, the PA patients had significantly higher baPWV compared to the EH patients. The AUC of haPWV was greater than that of baPWV. In conclusion, haPWV seems to be a better PWV parameter than baPWV in detecting aldosterone-induced arterial stiffness. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/621840 | ISSN: | 2227-9059 | DOI: | 10.3390/biomedicines9101285 |
顯示於: | 醫學系 |
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