Temporal Dynamics of Anti-Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Journal Volume
75
Journal Issue
1
Pages
E1192
Date Issued
2022-08-24
Author(s)
Shaw, Elana R
Rosen, Lindsey B
Dobbs, Kerry
Delmonte, Ottavia M
Ferré, Elise M N
Schmitt, Monica M
Imberti, Luisa
Quaresima, Virginia
Lionakis, Michail S
Notarangelo, Luigi D
Holland, Steven M
Su, Helen C
Abstract
Binding levels and neutralization activity of anti-type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging.
Subjects
COVID-19; IFN-α; IFN-ω; autoantibodies; convalescence
SDGs
Publisher
OXFORD UNIV PRESS INC
Type
journal article