An experimental model for ovarian cancer: propagation of ovarian cancer initiating cells and generation of ovarian cancer organoids
Journal
BMC cancer
Journal Volume
22
Journal Issue
1
Date Issued
2022-09-10
Author(s)
Chen, Yu-An
Lu, Chen-Yu
Yu, Chen-Wei
HSIN-FU CHEN
Abstract
Ovarian cancer (OC) is the most lethal gynecological cancer due to the recurrence of drug-resistance. Cancer initiating cells (CICs) are proposed to be responsible for the aggressiveness of OC. The rarity and difficulty of in vitro long-term cultivation of CICs challenge the development of CIC-targeting therapeutics. Reprogramming cancer cells into induced cancer initiating cell (iCICs) could be an approach to solve these. Several inducible CICs have been acquired by activating the expression of stemness genes in different cancer cells. However, few reports have demonstrated the feasibility in OC.
Subjects
Cancer-initiating cells (CICs); Induced ovarian cancer-initiating cells (iOCICs); Organoid and drug screening; Ovarian cancer (OC)
SDGs
Publisher
BMC
Type
journal article