https://scholars.lib.ntu.edu.tw/handle/123456789/624343
標題: | Nucleic acid amplification tests reduce delayed diagnosis and misdiagnosis of pulmonary tuberculosis | 作者: | Feng, Jia-Yih Lin, Chou-Jui JANN-YUAN WANG Chien, Shun-Tien Lin, Chih-Bin Huang, Wei-Chang Lee, Chih-Hsin CHIN-CHUNG SHU Yu, Ming-Chih Lee, Jen-Jyh Chiang, Chen-Yuan |
關鍵字: | MYCOBACTERIUM-TUBERCULOSIS; IMPACT; MTB/RIF | 公開日期: | 2022 | 出版社: | NATURE PORTFOLIO | 卷: | 12 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | The clinical impact of nucleic acid amplification (NAA) tests on reducing delayed diagnosis and misdiagnosis of pulmonary TB (PTB) has rarely been investigated. PTB patients were classified into a frontline NAA group, an add-on NAA group, and a no NAA group. The outcomes of interest were the proportion of PTB case died before anti-TB treatment, the interval between sputum examination and initiation of treatment, and misdiagnosis of PTB. A total of 2192 PTB patients were enrolled, including 282 with frontline NAA, 717 with add-on NAA, and 1193 with no NAA tests. Patients with NAA tests had a lower death rate before treatment initiation compared to those without NAA tests (1.6% vs. 4.4%, p < 0.001) in all cases. Patients with frontline NAA compared to those with add-on NAA and those without NAA, had a shorter interval between sputum examination and treatment initiation in all cases (3 days vs. 6 days (p < 0.001), vs 18 days (p < 0.001)), and less misdiagnosis in smear-positive cases (1.8% vs. 5.6% (p = 0.039), vs 6.5% (p = 0.026)). In conclusion, NAA tests help prevent death before treatment initiation. Frontline NAA tests perform better than add-on NAA and no NAA in avoiding treatment delay in all cases, and misdiagnosis of PTB in smear-positive cases. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/624343 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-022-16319-8 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。