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  1. NTU Scholars
  2. 醫學院
  3. 醫學檢驗暨生物技術學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/624376
Title: Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition
Authors: Chen, Rou-An
WEI-KAI WU 
Panyod, Suraphan
Liu, Po-Yu
Chuang, Hsiao-Li
Chen, Yi-Hsun
Lyu, Qiang
Hsu, Hsiu-Ching
Lin, Tzu-Lung
Shen, Ting-Chin David
Yang, Yu-Tang
Zou, Hsin-Bai
Huang, Huai-Syuan
Lin, Yu-En
CHIEH-CHANG CHEN 
Ho, Chi-Tang
HSIN-CHIH LAI 
MING-SHIANG WU 
Hsu, Cheng-Chih
Sheen, Lee-Yan
Keywords: bile acid metabolism; dietary exposure; early life; food safety; gut microbiota; low-dose antibiotic; metabolic disorder; obesity
Issue Date: 28-Jun-2022
Publisher: AMER SOC MICROBIOLOGY
Journal Volume: 7
Journal Issue: 3
Source: mSystems
Abstract: 
Antibiotics used as growth promoters in livestock and animal husbandry can be detected in animal-derived food. Epidemiological studies have indicated that exposure to these antibiotic residues in food may be associated with childhood obesity. Herein, the effect of exposure to a residual dose of tylosin-an antibiotic growth promoter-on host metabolism and gut microbiota was explored in vivo. Theoretical maximal daily intake (TMDI) doses of tylosin were found to facilitate high-fat-diet-induced obesity, induce insulin resistance, and perturb gut microbiota composition in mice. The obesity-related phenotypes were transferrable to germfree recipient mice, indicating that the effects of a TMDI dose of tylosin on obesity and insulin resistance occurred mainly via alteration of the gut microbiota. Tylosin TMDI exposure restricted to early life, the critical period of gut microbiota development, altered the abundance of specific bacteria related to host metabolic homeostasis later in life. Moreover, early-life exposure to tylosin TMDI doses was sufficient to modify the ratio of primary to secondary bile acids, thereby inducing lasting metabolic consequences via the downstream FGF15 signaling pathway. Altogether, these findings demonstrate that exposure to very low doses of antibiotic residues, whether continuously or in early life, could exert long-lasting effects on host metabolism by altering the gut microbiota and its metabolites. IMPORTANCE This study demonstrates that even with limited exposure in early life, a residual dose of tylosin might cause long-lasting metabolic disturbances by altering the gut microbiota and its metabolites. Our findings reveal that the gut microbiota is susceptible to previously ignored environmental factors.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/624376
ISSN: 2379-5077
DOI: 10.1128/msystems.00172-22
Appears in Collections:醫學檢驗暨生物技術學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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