Reverse cardiac remodelling and dysfunction in A97S transthyretin cardiac amyloidosis after tafamidis treatment
Journal
ESC heart failure
Journal Volume
9
Journal Issue
6
Pages
4335-4339
Date Issued
2022-12
Author(s)
Wu, Yuan-Kun Aden
Abstract
Transthyretin cardiomyopathy (ATTR-CM) is an under-recognized cause of heart failure, but it has received increasing attention due to the availability of treatment options. We present a case of hereditary transthyretin cardiomyopathy (A97S, an under-represented variant in current clinical studies) who presented with heart failure. Timely diagnosis and intervention with tafamidis demonstrated reversed cardiac remodelling via multiple imaging techniques (echocardiography, cardiac magnetic resonance imaging and technetium-99m pyrophosphate scintigraphy). The echocardiography and cardiac magnetic resonance imaging demonstrated improved global strain. Cardiac magnetic resonance imaging showed decreased extracellular volume. The technetium-99m pyrophosphate scintigraphy demonstrated decreased heart-to-contralateral ratio. This case highlights the potential reversible effect of tafamidis on A97S amyloidosis cardiomyopathy.
Subjects
Cardiac amyloidosis; Cardiac magnetic resonance imaging; Echocardiography; Tafamidis; Technetium-99m pyrophosphate scintigraphy
SDGs
Publisher
WILEY PERIODICALS, INC
Type
journal article