https://scholars.lib.ntu.edu.tw/handle/123456789/624394
標題: | Reverse cardiac remodelling and dysfunction in A97S transthyretin cardiac amyloidosis after tafamidis treatment | 作者: | Wu, Yuan-Kun Aden CHENG-HSUAN TSAI MAO-YUAN SU CHI-CHAO CHAO MEI-FANG CHENG CHIA-TUNG SHUN SUNG-TSANG HSIEH YEN-HUNG LIN |
關鍵字: | Cardiac amyloidosis; Cardiac magnetic resonance imaging; Echocardiography; Tafamidis; Technetium-99m pyrophosphate scintigraphy | 公開日期: | 十二月-2022 | 出版社: | WILEY PERIODICALS, INC | 卷: | 9 | 期: | 6 | 起(迄)頁: | 4335 | 來源出版物: | ESC heart failure | 摘要: | Transthyretin cardiomyopathy (ATTR-CM) is an under-recognized cause of heart failure, but it has received increasing attention due to the availability of treatment options. We present a case of hereditary transthyretin cardiomyopathy (A97S, an under-represented variant in current clinical studies) who presented with heart failure. Timely diagnosis and intervention with tafamidis demonstrated reversed cardiac remodelling via multiple imaging techniques (echocardiography, cardiac magnetic resonance imaging and technetium-99m pyrophosphate scintigraphy). The echocardiography and cardiac magnetic resonance imaging demonstrated improved global strain. Cardiac magnetic resonance imaging showed decreased extracellular volume. The technetium-99m pyrophosphate scintigraphy demonstrated decreased heart-to-contralateral ratio. This case highlights the potential reversible effect of tafamidis on A97S amyloidosis cardiomyopathy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/624394 | ISSN: | 2055-5822 | DOI: | 10.1002/ehf2.14165 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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