https://scholars.lib.ntu.edu.tw/handle/123456789/624991
標題: | Deriving in vivo biotransformation rate constants and metabolite parent concentration factor/stable metabolite factor from bioaccumulation and bioconcentration experiments: An illustration with worm accumulation data | 作者: | Kuo D.T.F Chen C.C. TA FU DAVE KUO |
關鍵字: | Bioaccumulation; Bioconcentration; Biotransformation; Metabolism; Risk assessment; Toxicokinetics | 公開日期: | 2016 | 卷: | 35 | 期: | 12 | 起(迄)頁: | 2903-2909 | 來源出版物: | Environmental Toxicology and Chemistry | 摘要: | Growing concern for the biological fate of organic contaminants and their metabolites and the urge to connect in vitro and in vivo toxicokinetics have prompted researchers to characterize the biotransformation behavior of organic contaminants in biota. The whole body biotransformation rate constant (kM) is currently determined by the difference approach, which has significant methodological limitations. A new approach for determining kM from the kinetic observations of the parent contaminant and its intermediate metabolites is proposed. In this method, kM can be determined by fitting kinetic data of the parent contaminant and the metabolites to analytical equations that depict the bioaccumulation kinetics. The application of the proposed method is illustrated using worm bioaccumulation–biotransformation data collected from the literature. Furthermore, a metabolite parent concentration factor (MPCF) is also proposed to characterize the persistence of the metabolite in biota. Because both the proposed kM method and MPCF build on the existing theoretical framework for bioaccumulation, they can be readily incorporated into standard experimental bioaccumulation protocols or risk assessment procedures or frameworks. Possible limitations, implications, and future directions are elaborated. Environ Toxicol Chem 2016;35:2903–2909. © 2016 SETAC. © 2016 SETAC |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979598033&doi=10.1002%2fetc.3509&partnerID=40&md5=e24e894ede55f96247eff75c422cdbb1 https://scholars.lib.ntu.edu.tw/handle/123456789/624991 |
ISSN: | 07307268 | DOI: | 10.1002/etc.3509 | SDG/關鍵字: | Bioaccumulation; Biochemistry; Bioconversion; Biomolecules; Contamination; Impurities; Kinetics; Metabolism; Metabolites; Risk assessment; Analytical equations; Bioaccumulation kinetics; Bioconcentration; Biotransformation; Concentration factors; Intermediate metabolites; Theoretical framework; Toxicokinetics; Rate constants; 1 hydroxypyrene; trinitrotoluene; 2-amino-4,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene; aniline derivative; organic compound; pyrene; pyrene derivative; analytical method; bioaccumulation; biotransformation; environmental fate; experimental study; laboratory method; metabolite; organic pollutant; persistence; reaction kinetics; risk assessment; Article; bioaccumulation; biotransformation; concentration (parameters); concentration at steady-state; conceptual framework; in vivo study; Lumbriculus variegatus; metabolite; nonhuman; Oligochaeta; priority journal; rate constant; Tubifex tubifex; animal; biotransformation; chemistry; kinetics; metabolism; Oligochaeta; Polychaeta; theoretical model; Aniline Compounds; Animals; Biotransformation; Kinetics; Models, Theoretical; Oligochaeta; Organic Chemicals; Polychaeta; Pyrenes |
顯示於: | 環境工程學研究所 |
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