https://scholars.lib.ntu.edu.tw/handle/123456789/625211
標題: | Contributions of acidic ions in secondary aerosol to PM2.5 bioreactivity in an urban area | 作者: | Laiman V TA-CHIH HSIAO Wang Y.-H Young L.-H Chao H.-R Lin T.-H Heriyanto D.S Chuang H.-C. |
關鍵字: | Air pollution; Inflammation; Oxidative stress; Particulate matter; Physicochemistry; Source apportionment | 公開日期: | 2022 | 卷: | 275 | 來源出版物: | Atmospheric Environment | 摘要: | Adverse human health effects caused by fine particulate matter (PM2.5) were reported; however, source-specific PM2.5 and its bioreactivity need to be assessed to understand regional human impacts. The objective of this study was to investigate the contributions of PM2.5 to particle bioreactivity in Taichung City, an urban area of west-central Taiwan. The average mass concentration of PM2.5 was 44.4 μg m−3 from 21 March to April 22, 2018. PM2.5 was identified from six distinct sources using a positive matrix factorization (PMF) model. Secondary aerosols were discovered to be the primary contributor to PM2.5 (25.58%), and were primarily composed of Cl−, NO3−, EC, NH4+, and SO42−. It was found that approximately 52.20% (23.2 μg m−3) of inhaled PM2.5 was deposited in the alveolar region after inhalation in the human lungs according to the multiple-path particle dosimetry (MPPD) model. Therefore, human alveolar epithelial A549 cells were exposed to PM2.5, which significantly reduced lung cell viability, and increased the cytotoxic lactate dehydrogenase (LDH), reactive oxygen species (ROS), and inflammatory interleukin (IL)-6 (p < 0.05). Next, we discovered positive correlation between secondary aerosols and ROS production, which was further linked to increases in inorganic ions (Mg2+, Cl−, NO3−, and SO42−) (p < 0.05). In conclusion, acidic ions from secondary aerosols were positively correlated with ROS production in human alveolar epithelial cells. Our results showed that secondary aerosols could be an important determinant of the deterioration of air quality and human respiratory health in urban areas. © 2022 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124955367&doi=10.1016%2fj.atmosenv.2022.119001&partnerID=40&md5=94e8f83d9ad2e53db998e75800cd9a77 https://scholars.lib.ntu.edu.tw/handle/123456789/625211 |
ISSN: | 13522310 | DOI: | 10.1016/j.atmosenv.2022.119001 | SDG/關鍵字: | Aerosols; Air quality; Bioactivity; Deterioration; Factorization; Ions; Bioreactivity; Fine particulate matter; Human health effects; Particulate Matter; Physicochemistry; PM 2.5; Reactive oxygen species; Secondary aerosols; Source apportionment; Urban areas; Particles (particulate matter); ammonia; carbon; dichlorodihydrofluorescein diacetate; interleukin 6; lactate dehydrogenase; magnesium ion; nitrate; reactive oxygen metabolite; sulfate; aerosol; air quality; health impact; particulate matter; pollution exposure; reactive oxygen species; urban area; A-549 cell line; air quality control; air sampling; Article; atmospheric deposition; biochemical analysis; biochemical composition; biological activity; cell viability; concentration (parameter); controlled study; dosimetry; human; inflammation; inhalation; lung alveolus; lung alveolus epithelium cell; non-negative matrix factorization; nonhuman; oxidative stress; particulate matter 2.5; PM2.5 exposure; pollution transport; respiratory system; secondary organic aerosol; Taiwan; urban area; Taichung; Taiwan |
顯示於: | 環境工程學研究所 |
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