https://scholars.lib.ntu.edu.tw/handle/123456789/625216
標題: | Blood Pressure Complexity Discriminates Pathological Beat-to-Beat Variability as a Marker of Vascular Aging | 作者: | Lee Y.-K Mazzucco S Rothwell P.M STEPHEN JOHN PAYNE Webb A.J.S. |
關鍵字: | arterial stiffness; baroreflex sensitivity; blood pressure variability; complexity; heart rate variability; stroke; transient ischemic attack | 公開日期: | 2022 | 卷: | 11 | 期: | 3 | 來源出版物: | Journal of the American Heart Association | 摘要: | BACKGROUND: Beat-to-beat blood pressure variability (BPV) is associated with an increased risk of stroke but can be driven by both healthy physiological processes and failure of compensatory mechanisms. Blood pressure (BP) complexity measures structured, organized variations in BP, as opposed to random fluctuations, and its reduction may therefore identify pathological beat-to-beat BPV. METHODS AND RESULTS: In the prospective, population-based OXVASC (Oxford Vascular Study) Phenotyped Cohort with transient ischemic attack or minor stroke, patients underwent at least 5 minutes of noninvasive beat-to-beat monitoring of BP (Finometer) and ECG to derive the following: BPV (coefficient of variation) and complexity (modified multiscale entropy) of systolic BP and diastolic BP, heart rate variability (SD of R-R intervals), and baroreflex sensitivity (BRS; Welch’s method), in low-(0.04– 0.15 Hz) and high-frequency (0.15– 0.4 Hz) bands. Associations between BPV or BP complexity with autonomic indexes and arterial stiffness were determined (linear regression), unadjusted, and adjusted for age, sex, and cardiovascular risk factors. In 908 consecutive, consenting patients, BP complexity was inversely correlated with BPV coefficient of variation (P<0.001) and was similarly reduced in patients with hypertension or diabetes (P<0.001). However, although BPV coefficient of variation had a U-shaped relationship with age, BP complexity fell systematically across age quintiles (quintile 1: 15.1 [14.0– 16.1] versus quintile 5: 13.8 [12.4–15.1]) and was correlated with markers of autonomic dysfunction (heart rate variability SD of R-R intervals: r = 0.20; BRS low frequency: 0.19; BRS high frequency: 0.26) and arterial stiffness (pulse wave velocity: −0.21; all P<0.001), even after adjustment for clinical variables (heart rate variability SD of R-R intervals: 0.12; BRS low frequency and BRS high frequency: 0.13 and 0.17; and pulse wave velocity: −0.07; all P<0.05). CONCLUSIONS: Loss of BP complexity discriminates BPV because of pathological failure of compensatory mechanisms and may represent a less confounded and potentially modifiable risk factor for stroke. © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123969892&doi=10.1161%2fJAHA.121.022865&partnerID=40&md5=31145aceeec00bb67540adae32448358 https://scholars.lib.ntu.edu.tw/handle/123456789/625216 |
ISSN: | 20479980 | DOI: | 10.1161/JAHA.121.022865 | SDG/關鍵字: | adult; age distribution; aged; aging; arterial stiffness; Article; autonomic dysfunction; baroreflex sensitivity; blood pressure monitoring; blood pressure variability; blood vessel parameters; cardiovascular risk factor; cerebrovascular accident; cohort analysis; controlled study; diabetes mellitus; diastolic blood pressure; electrocardiography; female; heart rate variability; human; hypertension; major clinical study; male; phenotype; population research; pressoreceptor reflex; prospective study; pulse wave velocity; sex difference; systolic blood pressure; transient ischemic attack; vascular aging; aging; blood pressure; cerebrovascular accident; heart rate; physiology; pulse wave; biological marker; Aging; Baroreflex; Biomarkers; Blood Pressure; Heart Rate; Humans; Prospective Studies; Pulse Wave Analysis; Stroke |
顯示於: | 應用力學研究所 |
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