Galectin-3 interacts with vascular cell adhesion molecule-1 to increase cardiovascular mortality in hemodialysis patients
Journal
Journal of Clinical Medicine
Journal Volume
7
Journal Issue
10
Date Issued
2018
Author(s)
Abstract
Background: Interactions and joint effects of galectin-3 and vascular cell adhesion molecule 1 (VCAM-1) on risks of all-cause and cardiovascular (CV) mortality remain unclear in patients with maintenance hemodialysis (MHD). Methods: Unadjusted and adjusted hazard ratios (aHRs) of mortality risks were analyzed between higher and lower concentration groups of serum galectin-3 and VCAM-1. The modification effect between serum galectin-3 and VCAM-1 on mortality risk was investigated using an interaction product term. Results: During follow-up, galectin-3 and VCAM-1 were associated with incremental risks of all-cause mortality (aHR: 1.038 (95% confidence interval (CI): 1.001–1.077) and 1.002 (95% CI: 1.001–1.003), respectively). Nonetheless, VCAM-1 but not galectin-3 predicted CV mortality (aHR: 1.043 (95% CI: 0.993–1.096) and 1.002 (95% CI: 1.001–1.003), respectively). In the interaction analysis, patients with combined higher galectin-3 (>29.5 ng/mL) and VCAM-1 (>1546.9 ng/mL) were at the greatest risk of all-cause and CV mortality (aHR: 4.6 (95% CI: 1.6–13.4), and 4.2 (95% CI: 1.3–14.4), respectively). The interactions between galectin-3 and VCAM-1 with respect to all-cause and CV mortality were statistically significant (p < 0.01 and < 0.05, respectively). Conclusion: Galectin-3 and VCAM-1 could serve as a promising dual biomarker for prognostic assessment, considering their joint effects on pathogenesis of leukocyte trafficking and atherothrombosis. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Subjects
Cell adhesion molecules; Galectin; Hemodialysis; Mortality
SDGs
Other Subjects
biological marker; C reactive protein; calcium; cholesterol; creatinine; galectin 3; glucose; hemoglobin; low density lipoprotein; phosphate; potassium; serum albumin; triacylglycerol; uric acid; vascular cell adhesion molecule 1; adult; ageism; all cause mortality; Article; blood pressure measurement; cardiovascular mortality; cohort analysis; controlled study; enzyme linked immunosorbent assay; female; follow up; hemodialysis; human; leukocyte migration; major clinical study; male; metabolic parameters; middle aged; mortality rate; mortality risk; normalized protein catabolic rate; prevalence; prognostic assessment; protein blood level; protein interaction; risk assessment; smoking
Type
journal article