https://scholars.lib.ntu.edu.tw/handle/123456789/625292
標題: | Eye orbit effects on eyeball resonant frequencies and acoustic tonometer measurements | 作者: | PO-JEN SHIH Wu S.-J Sung Y.-H Tung Y.-T Chang C.-Y Hatamie S Dai Z.-X. |
公開日期: | 2022 | 卷: | 12 | 期: | 1 | 來源出版物: | Scientific Reports | 摘要: | The eye orbit has mechanical and acoustic characteristics that determine resonant frequencies and amplify acoustic signals in certain frequency ranges. These characteristics also interfere with the acoustic amplitudes and frequencies of eyeball when measured with an acoustic tonometer. A model in which a porcine eyeball was embedded in ultrasonic conductive gel in the orbit of a model skull was used to simulate an in vivo environment, and the acoustic responses of eyeballs were detected. The triggering source was a low-power acoustic speaker contacting the occipital bone, and the detector was a high-resolution microphone with a dish detecting the acoustic signals without contacting the cornea. Dozens of ex vivo porcine eyeballs were tested at various intraocular pressure levels to detect their resonant frequencies and acoustic amplitudes in their power spectra. We confirmed that the eyeballs’ resonant frequencies were proportional to intraocular pressure, but interference from orbit effects decreased the amplitudes in these resonant frequency ranges. However, we observed that the frequency amplitudes of eyeballs were correlated with intraocular pressure in other frequency ranges. We investigated eye orbit effects and demonstrated how they interfere with the eyeball’s resonant frequencies and frequency amplitudes. These results are useful for developing advanced acoustic tonometer. © 2022, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126901458&doi=10.1038%2fs41598-022-08874-x&partnerID=40&md5=5b571debda182a17fd985bb9c0317693 https://scholars.lib.ntu.edu.tw/handle/123456789/625292 |
ISSN: | 20452322 | DOI: | 10.1038/s41598-022-08874-x | SDG/關鍵字: | acoustics; animal; cornea; intraocular pressure; oculoplethysmography; orbit; pig; procedures; Acoustics; Animals; Cornea; Intraocular Pressure; Orbit; Swine; Tonometry, Ocular |
顯示於: | 醫學工程學研究所 |
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