https://scholars.lib.ntu.edu.tw/handle/123456789/625342
標題: | Auditory independent low-intensity ultrasound stimulation of mouse brain is associated with neuronal ERK phosphorylation and an increase of Tbr2 marked neuroprogenitors | 作者: | Lim J Chu Y.-C Tai H.-H Chien A Huang S.-S Chen C.-C JAW-LIN WANG |
關鍵字: | ASIC1a; ASIC3; Auditory; Tbr2+ progenitor; Transcranial ultrasound | 公開日期: | 2022 | 卷: | 613 | 起(迄)頁: | 113-119 | 來源出版物: | Biochemical and Biophysical Research Communications | 摘要: | Transcranial ultrasound stimulation is an emerging technique for the development of a non-invasive neuromodulation device for the treatment of various types of neurodegenerations and brain damages. However, there are very few studies that have quantified the optimal ultrasound dosage and the long-term associated effects of transcranial ultrasound treatments of brain diseases. In this study, we used a simple ex vivo hippocampal tissues stimulated by different dosages of ultrasound in combination with different chemical treatments to quantify the required energy for a measurable effect. After determining the most desirable ex vivo stimulation conditions, it was then replicated for the in vivo mouse brains. It was discovered that transcranial ultrasound promoted the increase of Tbr2-expressing neural progenitors in an ASIC1a-dependent manner. Furthermore, such effect was observable at least a week after the initial ultrasound treatments and was not abolished by auditory toxicity. © 2022 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129751036&doi=10.1016%2fj.bbrc.2022.04.123&partnerID=40&md5=4af5291e4813d0af27556573a6e65baa https://scholars.lib.ntu.edu.tw/handle/123456789/625342 |
ISSN: | 0006291X | DOI: | 10.1016/j.bbrc.2022.04.123 | SDG/關鍵字: | acid sensing ion channel; acid sensing ion channel 1a; eomesodermin; furosemide; kanamycin; mitogen activated protein kinase 1; unclassified drug; animal experiment; animal model; animal tissue; Article; auditory stimulation; brain depth stimulation; chemical stimulation; controlled study; energy yield; enzyme phosphorylation; ex vivo study; low intensity ultrasound; mouse; nerve cell stimulation; neural stem cell; neuromodulation; nonhuman; protein expression; animal; auditory stimulation; brain; echography; nerve cell; phosphorylation; physiology; procedures; Acoustic Stimulation; Animals; Brain; Mice; Neurons; Phosphorylation; Ultrasonography |
顯示於: | 醫學工程學研究所 |
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