Cellular studies via dielectrophoresisbased cellular microarray chip

Abstract

This paper reports a dielectrophoresis (DEP)-based cellular microarray platform with embedded concentration gradient generator for cellular studies. Positive DEP was applied to pattern cells on collagen-coated substrate. Results show the approach requires fewer cells, compared to conventional approaches, to be patterned in microarray within minutes and with good uniformity. Further, the embedded concentration gradient generator provides concentrations with high repeatability. High cell viability is obtained after 24 hours incubation. The cellular microarray would allow batch testing with different drug/reagent concentrations in a single chip for high-throughput cellular studies. © 2007 CBMS.