An improved Ullmann-Ukita-Buchwald-Li conditions for CuI-catalyzed coupling reaction of 2-pyridones with aryl halides
Journal
Tetrahedron
Journal Volume
61
Journal Issue
11
Pages
2931-2939
Date Issued
2005
Author(s)
Abstract
An effective CuI-trans-N,N′-dimethylcyclohexane-1,2-diamine (DMCDA)-K2CO3-catalyzed coupling reaction of 2-pyridones with aryl halides is described. Under our conditions, DMCDA was found to be an effective catalyst that facilitates the coupling reactions even in toluene, a common industrial solvent. In addition, 3-bromopyridine could also be coupled effectively under these conditions, indicating that the catalytic reactivity of this system is high. The reaction could be applied for polymer modification and iterative oligo-pyridone synthesis. © 2005 Elsevier Ltd. All rights reserved.
Subjects
2-Pyridones; C-N coupling; Copper reagents; Toluene
Other Subjects
copper derivative; halide; pyridone derivative; toluene; article; catalysis; chemical modification; chemical reaction kinetics; priority journal
Type
journal article