https://scholars.lib.ntu.edu.tw/handle/123456789/626211
標題: | An update on mesoporous silica nanoparticle applications in nanomedicine | 作者: | Rastegari E Hsiao Y.-J Lai W.-Y Lai Y.-H Yang T.-C Chen S.-J Huang P.-I Chiou S.-H CHUNG-YUAN MOU Chien Y. |
關鍵字: | Bioimaging; Cancer therapy; Mesoporous silica nanoparticles; Stem cell research; Tissue engineering | 公開日期: | 2021 | 卷: | 13 | 期: | 7 | 來源出版物: | Pharmaceutics | 摘要: | The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances in the design and engineering of nanocarrier systems with supra-molecular structures. Smart mesoporous silica nanoparticles (MSNs), with excellent biocompatibility, tunable physicochemical properties, and site-specific functionalization, offer efficient and high loading capacity as well as robust and targeted delivery of a variety of payloads in a controlled fashion. Such unique nanocarriers should have great potential for challenging biomedical applications, such as tissue engineering, bioimaging techniques, stem cell research, and cancer therapies. However, in vivo applications of these nanocarriers should be further validated before clinical translation. To this end, this review begins with a brief introduction of MSNs properties, targeted drug delivery, and controlled release with a particular emphasis on their most recent diagnostic and therapeutic applications. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111044334&doi=10.3390%2fpharmaceutics13071067&partnerID=40&md5=cd1ad77cd4e4eedde6636cfb2c4a06e1 https://scholars.lib.ntu.edu.tw/handle/123456789/626211 |
ISSN: | 19994923 | DOI: | 10.3390/pharmaceutics13071067 | SDG/關鍵字: | mesoporous silica nanoparticle; nanocarrier; reactive oxygen metabolite; ablation therapy; antibacterial activity; biocompatibility; biofilm; bone tissue; cancer therapy; cell differentiation; chemotherapy; drug delivery system; drug release; flow cytometry; gene therapy; human; imaging; immunotherapy; loading drug dose; mouse; MTT assay; nanomedicine; nonhuman; nuclear magnetic resonance imaging; photodynamic therapy; physical chemistry; pluripotent stem cell; positron emission tomography; Review; sonodynamic therapy; stem cell research; tissue engineering; vascular tissue; wound healing |
顯示於: | 化學系 |
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