https://scholars.lib.ntu.edu.tw/handle/123456789/626331
標題: | Poly-quercetin-based nanoVelcro as a multifunctional wound dressing for effective treatment of chronic wound infections | 作者: | Li Y.-J Wei S.-C Chu H.-W Jian H.-J Anand A Nain A Huang Y.-F HUAN-TSUNG CHANG Huang C.-C Lai J.-Y. |
關鍵字: | Antimicrobials; Chronic wounds; Multidrug-resistant bacteria; Phytochemicals; Wound dressing | 公開日期: | 2022 | 卷: | 437 | 來源出版物: | Chemical Engineering Journal | 摘要: | Comprehensive wound dressings for bacterial wound treatment requires a combination of antibacterial, antioxidative, and anti-inflammatory effects and endotoxin neutralization. Here, we report a novel nanoVelcro dressing made from quercetin (QNV) through alkaline-mediated catalytic polymerization and crosslinking. These dressings can effectively inhibit the growth of Gram-negative, Gram-positive and multidrug-resistant bacteria in complicated medium (e.g., human plasma) through ultrastrong bacterial wrapping. QNV shows a minimum inhibitory concentration (MIC) of 10 μg mL−1 against the tested bacteria, which is 5-fold lower than that of monomeric quercetin. In addition to its superior antibacterial activity, QNV exhibits the inherent antioxidative and inflammatory activities of quercetin. More importantly, QNV wrapping further prevents bacteria from releasing toxins during infection, inhibiting the subsequent inflammatory response. QNV, in contrast to silver nanoparticles and 3 M wound care dressings, effectively inhibits bacterial growth and wound inflammation in methicillin-resistant Staphylococcus aureus (MRSA) − infected wounds in diabetic mice by accelerating the wound closure rate. Our results reveal that the use of QNV in the design of an ultrastrong bacterial binder is promising for the development of multifunctional wound dressings for the treatment of chronic infectious wounds. © 2022 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124823604&doi=10.1016%2fj.cej.2022.135315&partnerID=40&md5=cf97c21fecebac67dae85d87cbaf889f https://scholars.lib.ntu.edu.tw/handle/123456789/626331 |
ISSN: | 13858947 | DOI: | 10.1016/j.cej.2022.135315 | SDG/關鍵字: | Bacteria; Mammals; Phenols; Silver nanoparticles; Anti-inflammatory effects; Antibacterials; Antioxidative; Chronic wounds; Multidrug resistants; Multidrug-resistant bacteria; Phytochemical; Resistant bacteria; Wound dressings; Wound infections; Flavonoids |
顯示於: | 化學系 |
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