https://scholars.lib.ntu.edu.tw/handle/123456789/626385
標題: | Total Synthesis and Antimicrobial Evaluation of Pagoamide A | 作者: | Wu C.-H John Chu |
關鍵字: | antimicrobial activity; Hantzsch thiazole synthesis; marine natural products; pagoamide A; solid-phase peptide synthesis; total synthesis | 公開日期: | 2021 | 卷: | 9 | 來源出版物: | Frontiers in Chemistry | 摘要: | Natural products are often the starting point for drug development and also the testing ground for synthetic methods. Herein we describe the total synthesis and antimicrobial evaluation of a marine natural product, pagoamide A, which is a macrocyclic depsipeptide with two backbone thiazole units and a dimethylated N-terminus. The two thiazole building blocks were synthesized from commercially available materials in four or fewer steps and employed directly in solid-phase peptide synthesis (SPPS) to afford pagoamide A. The use of SPPS ensured that the synthetic sequence is operationally straightforward and, if needed, permits modular substitution of building blocks to easily access diverse structural analogs. Our antimicrobial assays showed that pagoamide A has moderate activity against Bacillus subtilis. © Copyright © 2021 Wu and Chu. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115990774&doi=10.3389%2ffchem.2021.741290&partnerID=40&md5=40ef75c36c4747314096943ad15970d9 https://scholars.lib.ntu.edu.tw/handle/123456789/626385 |
ISSN: | 22962646 | DOI: | 10.3389/fchem.2021.741290 |
顯示於: | 化學系 |
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