H2O2 accumulation mediates differentiation capacity alteration, but not proliferative decline, in senescent human fetal mesenchymal stem cells
Journal
Antioxidants & redox signaling
Journal Volume
18
Journal Issue
15
Pages
1895
Date Issued
2013-05-20
Author(s)
Abstract
Mesenchymal stem cells (MSCs) with multilineage differentiation capacity and immunomodulatory properties are novel sources for cell therapy. However, in vitro expansion of these rare somatic stem cells leads to senescence, resulting in declines of differentiation and proliferative capacities. We therefore investigated the mechanisms mediating senescence in human fetal MSCs termed placenta-derived multipotent cells (PDMCs).
Subjects
PROTEIN-KINASE-C; CELLULAR SENESCENCE; MULTIPOTENT CELLS; ROS PRODUCTION; STROMAL CELLS; BONE-MARROW; EPITHELIAL-CELLS; IN-VITRO; AGE; SIRT1
Publisher
MARY ANN LIEBERT, INC
Type
journal article