https://scholars.lib.ntu.edu.tw/handle/123456789/626478
標題: | Versatile Azido-Functionalized Carbon Dots for Cancer Cell Imaging | 作者: | Lee, HY Chiang, PY Wu, HJ Wang, TY Yang, TC Cheng, Wei-Chieh LEE-CHIANG LO WEI-SSU LIAO |
關鍵字: | fluorescence; metal-free; click chemistry; folate; cellular imaging; QUANTUM DOTS; CLICK; FLUORESCENCE; MECHANISM | 公開日期: | 2022 | 出版社: | AMER CHEMICAL SOC | 卷: | 5 | 期: | 9 | 來源出版物: | ACS APPLIED NANO MATERIALS | 摘要: | Herein, we adopt a bottom-up approach to achieve the first one-pot synthesis of azido-functionalized carbon dots (CDs) through a unique glucose-azidoamine two-component recipe. The azido content on CDs can be well-tuned by partially replacing the azidoamine with a methoxyamine diluent during the synthesis. Task-oriented payloads could then be conveniently connected to the azido-functionalized CDs through click chemistry. As a demonstration, we exploit strain-promoted alkyne-azide cycloaddition to obtain folate-decorated CDs, which can selectively display fluorescence in tumor cell lines with elevated levels of folate receptors. This facile production of azido-functionalized CDs should provide huge advantages for future applications. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626478 | ISSN: | 2574-0970 | DOI: | 10.1021/acsanm.2c01766 |
顯示於: | 化學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。