https://scholars.lib.ntu.edu.tw/handle/123456789/626590
Title: | Demethylation of an artificial hydrogenase agent for prolonged CO release and enhanced anti-tau aggregation activity | Authors: | Wu, Yun-Chin Liu, Yu-Chiao Tsai, Shu-Wei Chu, Kai-Ti Chen, Hsin-Jou Wu, Cheng-Yun Hsu, Yu-Yi Hsieh, Chang-Chih Liu, Wang-Jing KIEN-VOON KONG Chiang, Ming-Hsi |
Keywords: | CARBON-MONOXIDE; PROTON | Issue Date: | 28-Jun-2022 | Publisher: | ROYAL SOC CHEMISTRY | Journal Volume: | 58 | Journal Issue: | 52 | Start page/Pages: | 7245 | Source: | Chemical communications (Cambridge, England) | Abstract: | Carbon monoxide (CO) plays an important role in signaling in cells, making its use as a therapeutic tool highly intriguing. Reduced burst emissions are important to avoid the cytotoxicity and tissue damage caused by CO. Here, we developed a stable diiron carbonyl [FeFe] hydrogenase agent that enables prolonged CO release activity (half-life of over 9 h) in cells. The integrated analysis allowed the identification of the key intermediate sites and CO accumulations with subcellular resolution. We observed that the [FeFe]A complex was enriched in neurons with S-methyl bond rupture. Furthermore, the [FeFe]A complex efficiently reduced the aggregation of tau proteins (49.3% reduction) and showed superior biocompatibility in nerve cells (∼ 95% survival). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626590 | ISSN: | 13597345 | DOI: | 10.1039/d2cc02119f |
Appears in Collections: | 化學系 |
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