https://scholars.lib.ntu.edu.tw/handle/123456789/626591
標題: | Merocyanine Complexes Coupled with Plasmonic Au Nanoparticles for Inhibiting Tau Aggregation | 作者: | Wu, YC Wu, Cheng-Yun Tsai, SW Chen, HJ Liu, WJ Lin, D Gong, TX Yong, KT KIEN-VOON KONG |
關鍵字: | plasmonic gold nanoparticles; photodynamic therapy; spiropyran hydrogel; nanomedicine; light-responsive nanomaterials; ALZHEIMERS-DISEASE; PHOTODYNAMIC THERAPY; CELLULAR UPTAKE; SPIROPYRAN; PROTEIN; BETA; PHOTODEGRADATION; PHOSPHORYLATION; PHOTOCHROMISM; RELEASE | 公開日期: | 2022 | 出版社: | AMER CHEMICAL SOC | 來源出版物: | ACS APPLIED NANO MATERIALS | 摘要: | Singlet oxygen (1O2) has been recently identified as the key mechanism for depressing β-amyloid (Aβ) accumulation and neurofibrillary tangles (NFTs). Slow cell internalization and short half-life of photosensitizing effects still impede the application of nanophotosensitizers for photodynamic therapy (PDT). The current major challenge of using spiropyran for PDT is the extremely short half-life of its ring-opened isomer, merocyanine. Merocyanine is the center of generation of 1O2. Here, we report that the complexation of spiropyran onto Au nanoparticles greatly enhances the stability of merocyanine (half-life is 91.6 h). Additionally, Au nanoparticles sharply decelerate the reversion of merocyanine back to spiropyran (a ring-closed form) by modifying the energy configuration of merocyanine, resulting in generation of a long-lived 1O2 phototherapy response (24 h) in the intracellular environment for depressing tau aggregation (a 32% reduction of NFT formation). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626591 | ISSN: | 2574-0970 | DOI: | 10.1021/acsanm.2c03326 |
顯示於: | 化學系 |
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