https://scholars.lib.ntu.edu.tw/handle/123456789/626655
標題: | Prognostic factors of afatinib as a first-line therapy for advanced EGFR mutation-positive lung adenocarcinoma: a real-world, large cohort study | 作者: | SHENG-KAI LIANG MENG-RUI LEE WEI-YU LIAO CHAO-CHI HO JEN-CHUNG KO JIN-YUAN SHIH |
關鍵字: | EGFR mutation-positive lung adenocarcinoma; afatinib; first-line therapy; prognostic factor; real-world study | 公開日期: | 4-五月-2018 | 卷: | 9 | 期: | 34 | 來源出版物: | Oncotarget | 摘要: | Lung cancer remains the primary cause of cancer-related mortality worldwide. Several treatment modalities are available for lung cancer, including surgery, radiation, and chemotherapy. Among the chemotherapeutics available, afatinib has been shown to be effective for those with epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma. Herein, we analyzed the factors affecting the prognosis of patients who received afatinib as a first-line therapy for advanced EGFR mutation-positive lung adenocarcinoma in the real-world setting. Patients who received afatinib as a first-line therapy and were reimbursed by the National Health Insurance were recruited in this study. Data on patient characteristics and treatment courses were collected. In total, 259 patients were enrolled (median follow-up, 22.0 months). Of them, 82 (31.7%) were identified to have brain metastases at baseline, which were associated with poor Eastern Cooperative Oncology Group performance status, high incidence of central nervous system progression, and short overall survival. However, the results of our analysis showed that overall survival was not affected by reductions in the afatinib dosage or any upfront local treatments for brain tumors. Multivariate analyses showed that brain metastases at diagnosis and treatment response to afatinib are two important prognostic factors for the overall survival of patients with EGFR mutation-positive lung adenocarcinoma. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626655 | ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.25255 |
顯示於: | 醫學系 |
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