Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach
Journal
The British journal of psychiatry : the journal of mental science
Journal Volume
220
Journal Issue
4
Pages
219
Date Issued
2022-02-28
Author(s)
Cearns, Micah
Amare, Azmeraw T
Schubert, Klaus Oliver
Thalamuthu, Anbupalam
Frank, Joseph
Streit, Fabian
Adli, Mazda
Akula, Nirmala
Akiyama, Kazufumi
Ardau, Raffaella
Arias, Bárbara
Aubry, Jean-Michel
Backlund, Lena
Bhattacharjee, Abesh Kumar
Bellivier, Frank
Benabarre, Antonio
Bengesser, Susanne
Biernacka, Joanna M
Birner, Armin
Brichant-Petitjean, Clara
Cervantes, Pablo
Chillotti, Caterina
Cichon, Sven
Cruceanu, Cristiana
Czerski, Piotr M
Dalkner, Nina
Dayer, Alexandre
Degenhardt, Franziska
Zompo, Maria Del
DePaulo, J Raymond
Étain, Bruno
Falkai, Peter
Forstner, Andreas J
Frisen, Louise
Frye, Mark A
Fullerton, Janice M
Gard, Sébastien
Garnham, Julie S
Goes, Fernando S
Grigoroiu-Serbanescu, Maria
Grof, Paul
Hashimoto, Ryota
Hauser, Joanna
Heilbronner, Urs
Herms, Stefan
Hoffmann, Per
Hofmann, Andrea
Hou, Liping
Hsu, Yi-Hsiang
Jamain, Stephane
Jiménez, Esther
Kahn, Jean-Pierre
Kassem, Layla
Kato, Tadafumi
Kelsoe, John
Kittel-Schneider, Sarah
Kliwicki, Sebastian
König, Barbara
Kusumi, Ichiro
Laje, Gonzalo
Landén, Mikael
Lavebratt, Catharina
Leboyer, Marion
Leckband, Susan G
Maj, Mario
Manchia, Mirko
Martinsson, Lina
McCarthy, Michael J
McElroy, Susan
Colom, Francesc
Mitjans, Marina
Mondimore, Francis M
Monteleone, Palmiero
Nievergelt, Caroline M
Nöthen, Markus M
Novák, Tomas
O'Donovan, Claire
Ozaki, Norio
Millischer, Vincent
Papiol, Sergi
Pfennig, Andrea
Pisanu, Claudia
Potash, James B
Reif, Andreas
Reininghaus, Eva
Rouleau, Guy A
Rybakowski, Janusz K
Schalling, Martin
Schofield, Peter R
Schweizer, Barbara W
Severino, Giovanni
Shekhtman, Tatyana
Shilling, Paul D
Shimoda, Katzutaka
Simhandl, Christian
Slaney, Claire M
Squassina, Alessio
Stamm, Thomas
Stopkova, Pavla
Tekola-Ayele, Fasil
Tortorella, Alfonso
Turecki, Gustavo
Veeh, Julia
Vieta, Eduard
Witt, Stephanie H
Roberts, Gloria
Zandi, Peter P
Alda, Martin
Bauer, Michael
McMahon, Francis J
Mitchell, Philip B
Schulze, Thomas G
Rietschel, Marcella
Clark, Scott R
Baune, Bernhard T
Abstract
Response to lithium in patients with bipolar disorder is associated with clinical and transdiagnostic genetic factors. The predictive combination of these variables might help clinicians better predict which patients will respond to lithium treatment.
Subjects
Mood stabilisers; bipolar affective disorders; depressive disorders; genetics; outcome studies
Publisher
CAMBRIDGE UNIV PRESS
Type
journal article