https://scholars.lib.ntu.edu.tw/handle/123456789/626808
Title: | Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours | Authors: | Huang, Hsi-Chien Sung, Yun-Chieh Li, Chung-Pin Wan, Dehui Chao, Po-Han Tseng, Yu-Ting Liao, Bo-Wen HUI-TENG CHENG Hsu, Fu-Fei Huang, Chieh-Cheng Chen, Yi-Ting Liao, Yu-Hui Hsieh, Hsin Tzu Shih, Yu-Chuan Liu, I-Ju Wu, Han-Chung Lu, Tsai-Te JANE WANG Chen, Yunching |
Keywords: | drug resistance; fibrosis; pancreatic cancer | Issue Date: | Sep-2022 | Publisher: | BMJ PUBLISHING GROUP | Journal Volume: | 71 | Journal Issue: | 9 | Start page/Pages: | 1843 | Source: | Gut | Abstract: | Stromal barriers, such as the abundant desmoplastic stroma that is characteristic of pancreatic ductal adenocarcinoma (PDAC), can block the delivery and decrease the tumour-penetrating ability of therapeutics such as tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), which can selectively induce cancer cell apoptosis. This study aimed to develop a TRAIL-based nanotherapy that not only eliminated the extracellular matrix barrier to increase TRAIL delivery into tumours but also blocked antiapoptotic mechanisms to overcome TRAIL resistance in PDAC. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626808 | ISSN: | 0017-5749 | DOI: | 10.1136/gutjnl-2021-325180 |
Appears in Collections: | 醫學系 |
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