https://scholars.lib.ntu.edu.tw/handle/123456789/626814
標題: | Newly-diagnosed immunoglobulin A nephropathy with increased plasma galactose-deficient-IgA1 antibody associated with mRNA COVID-19 vaccination: a case report | 作者: | Chen, Yun-Sung Yang, Cheng-Wen Tsai, Chien-Chen Ang, Min-De Chou, San-Fang WEN-CHIH CHIANG Chiu, Yen-Ling |
關鍵字: | Acute kidney injury; COVID-19 vaccination; case report; galactose-deficient IgA1; immunoglobulin A nephropathy | 公開日期: | 十月-2022 | 出版社: | SAGE PUBLICATIONS LTD | 卷: | 50 | 期: | 10 | 來源出版物: | The Journal of international medical research | 摘要: | Newly-diagnosed or relapses of immunoglobulin A nephropathy (IgAN) have been associated with COVID-19 vaccination in the literature. Most reported cases were mild clinical diseases characterized by microscopic haematuria and do not require dialysis treatment. This current case report describes a 55-year-old male patient that presented to the emergency department with acute kidney injury after receiving the first dose of the mRNA-1273 COVID-19 vaccine. After admission, his renal function deteriorated rapidly, and then he developed uraemic encephalopathy. He underwent emergency haemodialysis with a rapid improvement in his mental status. Renal biopsy showed newly-diagnosed IgA nephropathy along with markedly elevated plasma level of galactose-deficient-IgA1 (Gd-IgA1) antibody. The patient did not receive immunosuppressive treatment and is now dialysis-free. Immune activation is considered an essential factor in developing or exacerbating IgAN following COVID-19 vaccination. This current case report demonstrates that elevated Gd-IgA1 antibody may be the potential mechanistic link between COVID-19 vaccination and IgAN. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626814 | ISSN: | 0300-0605 | DOI: | 10.1177/03000605221129674 |
顯示於: | 醫學系 |
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