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  4. Detection of SARS-associated coronavirus in throat wash and saliva in early diagnosis
 
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Detection of SARS-associated coronavirus in throat wash and saliva in early diagnosis

Journal
Emerging infectious diseases
Journal Volume
10
Journal Issue
7
Date Issued
2004-07
Author(s)
Wang, Wei-Kung
SHEY-YING CHEN  
Liu, I-Jung
YEE-CHUN CHEN  
Hui-Ling Chen  
Yang, Chao-Fu
PEI-JER CHEN  
Shiou-Hwei Yeh  
CHUAN-LIANG KAO  
LI-MIN HUANG  
PO-REN HSUEH  
JANN-TAY WANG  
WANG-HUEI SHENG  
CHI-TAI FANG  
CHIEN-CHING HUNG  
SZU-MIN HSIEH  
Su, Chan-Ping
WEN-CHU CHIANG  
Yang, Jyh-Yuan
Lin, Jih-Hui
Hsieh, Szu-Chia
Hu, Hsien-Ping
Chiang, Yu-Ping
JIN-TOWN WANG  
PAN-CHYR YANG  
SHAN-CHWEN CHANG  
DOI
10.3201/eid1007.031113
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/626858
URL
https://scholars.lib.ntu.edu.tw/handle/123456789/417202
Abstract
The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is thought to be transmitted primarily through dispersal of droplets, but little is known about the load of SARS-CoV in oral droplets. We examined oral specimens, including throat wash and saliva, and found large amounts of SARS-CoV RNA in both throat wash (9.58 x 10(2) to 5.93 x 10(6) copies/mL) and saliva (7.08 x 10(3) to 6.38 x 10(8) copies/mL) from all specimens of 17 consecutive probable SARS case-patients, supporting the possibility of transmission through oral droplets. Immunofluorescence study showed replication of SARS-CoV in the cells derived from throat wash, demonstrating the possibility of developing a convenient antigen detection assay. This finding, with the high detection rate a median of 4 days after disease onset and before the development of lung lesions in four patients, suggests that throat wash and saliva should be included in sample collection guidelines for SARS diagnosis.
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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