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Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/626858
Title: Detection of SARS-associated coronavirus in throat wash and saliva in early diagnosis
Authors: Wang, Wei-Kung
SHEY-YING CHEN 
Liu, I-Jung
YEE-CHUN CHEN 
Hui-Ling Chen 
Yang, Chao-Fu
PEI-JER CHEN 
Shiou-Hwei Yeh 
CHUAN-LIANG KAO 
LI-MIN HUANG 
PO-REN HSUEH 
JANN-TAY WANG 
WANG-HUEI SHENG 
CHI-TAI FANG 
CHIEN-CHING HUNG 
SZU-MIN HSIEH 
Su, Chan-Ping
WEN-CHU CHIANG 
Yang, Jyh-Yuan
Lin, Jih-Hui
Hsieh, Szu-Chia
Hu, Hsien-Ping
Chiang, Yu-Ping
JIN-TOWN WANG 
PAN-CHYR YANG 
SHAN-CHWEN CHANG 
Issue Date: Jul-2004
Journal Volume: 10
Journal Issue: 7
Source: Emerging infectious diseases
Abstract: 
The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is thought to be transmitted primarily through dispersal of droplets, but little is known about the load of SARS-CoV in oral droplets. We examined oral specimens, including throat wash and saliva, and found large amounts of SARS-CoV RNA in both throat wash (9.58 x 10(2) to 5.93 x 10(6) copies/mL) and saliva (7.08 x 10(3) to 6.38 x 10(8) copies/mL) from all specimens of 17 consecutive probable SARS case-patients, supporting the possibility of transmission through oral droplets. Immunofluorescence study showed replication of SARS-CoV in the cells derived from throat wash, demonstrating the possibility of developing a convenient antigen detection assay. This finding, with the high detection rate a median of 4 days after disease onset and before the development of lung lesions in four patients, suggests that throat wash and saliva should be included in sample collection guidelines for SARS diagnosis.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/626858
ISSN: 1080-6040
DOI: 10.3201/eid1007.031113
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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